Four independent studies shed light on the specificity of RNA-guided genome editing tools based on the Streptococcus pyogenes Cas9 protein.
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References
Jasin, M. Trends Genet. 12, 224–228 (1996).
Carroll, D. Genetics 188, 773–782 (2011).
Joung, J.K. & Sander, J.D. Nat. Rev. Mol. Cell Biol. 14, 49–55 (2013).
Fu, Y. et al. Nat. Biotechnol. 31, 822–826 (2013).
Hsu, P.D. et al. Nat. Biotechnol. 31, 827–832 (2013).
Mali, P. et al. Nat. Biotechnol. 31, 833–838 (2013).
Pattanayak, V. et al. Nat. Biotechnol. 31, 839–843 (2013).
Sorek, R., Lawrence, C.M. & Wiedenheft, B. Annu. Rev. Biochem. 82, 237–266 (2013).
Cong, L. et al. Science 339, 819–823 (2013).
Cho, S.W., Kim, S., Kim, J.M. & Kim, J.-S. Nat. Biotechnol. 31, 230–232 (2013).
Jinek, M. et al. eLife 2, e00471 (2013).
Mali, P. et al. Science 339, 823–826 (2013).
Jiang, W., Bikard, D., Cox, D., Zhang, F. & Marraffini, L.A. Nat. Biotechnol. 31, 233–239 (2013).
Wang, H. et al. Cell Reports 153, 910–918 (2013).
Li, D. et al. Nat. Biotechnol. 31, 681–683 (2013).
Li, W., Teng, F., Li, T. & Zhou, Q. Nat. Biotechnol. 31, 684–686 (2013).
Jao, L.-E., Wente, S.R. & Chen, W. Proc. Natl. Acad. Sci. USA (2013) Epub ahead of print doi:10.1073/pnas.1308335110.
Li, J.F. et al. Nat. Biotechnol. 31, 688–691 (2013).
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Carroll, D. Staying on target with CRISPR-Cas. Nat Biotechnol 31, 807–809 (2013). https://doi.org/10.1038/nbt.2684
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DOI: https://doi.org/10.1038/nbt.2684
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