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Nuclei facing the tissue surface get fuel for development

Using tissue from the developing fruit-fly wing, researchers show that a nucleus’s location in the cell determines how it experiences signals that regulate genes needed for proper wing formation.
  1. Tanvi Kulkarni

    1. Tanvi Kulkarni is at the Max Planck Institute of Immunobiology and Epigenetics, and in the Faculty of Biology, University of Freiburg, 79104 Freiburg im Breisgau, Germany.

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  2. Asifa Akhtar

    1. Asifa Akhtar is at the Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg im Breisgau, Germany.

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The development of specialized tissues relies on the intricate interplay between various cellular mechanisms, and the careful control over the timing and location of these processes. Writing in Nature, Willnow and Teleman1 uncover a developmental process that is influenced by a cell’s nuclear position with respect to the tissue’s surface.

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Nature 630, 312-314 (2024)

doi: https://doi.org/10.1038/d41586-024-01503-9

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Competing Interests

The authors declare no competing interests.

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