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  • NEWS FEATURE

Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?

Investigations suggest that, in some fields, at least one-quarter of clinical trials might be problematic or even entirely made up, warn some researchers. They urge stronger scrutiny.
  1. Richard Van Noorden

    1. Richard Van Noorden is a features editor at Nature in London.

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How many clinical-trial studies in medical journals are fake or fatally flawed? In October 2020, John Carlisle reported a startling estimate1.

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Nature 619, 454-458 (2023)

doi: https://doi.org/10.1038/d41586-023-02299-w

References

  1. Carlisle, J. B. Anaesthesia 76, 472–479 (2021).

    Article  PubMed  Google Scholar 

  2. Roberts, I., Smith, R. & Evans, S. BMJ 334, 392 (2007).

    Article  PubMed  Google Scholar 

  3. Avenell, A., Bolland, M. J., Gamble, G. D. & Grey, A. Account. Res. https://doi.org/10.1080/08989621.2022.2082290 (2022).

    Article  Google Scholar 

  4. Popp, M. et al. Cochrane Database Syst. Rev. 6, CD015017 (2022).

    Article  PubMed  Google Scholar 

  5. Ker, K., Shakur, H. & Roberts, I. BJOG 123, 1745–1752 (2016).

    Article  PubMed  Google Scholar 

  6. WOMAN Trial Collaborators. Lancet 389, 2105–2116 (2017).

    Article  PubMed  Google Scholar 

  7. Bellos, I. & Pergialiotis, V. Am. J. Obstet. Gynecol. 226, 510–523 (2021).

    Article  PubMed  Google Scholar 

  8. Pacheco, L. D. et al. N. Engl. J. Med. 388, 1365–1375 (2023).

    Article  PubMed  Google Scholar 

  9. Sotiriadis, A. et al. Cochrane Database Syst. Rev. 8, CD006614 (2018).

    Article  PubMed  Google Scholar 

  10. Sotiriadis, A. et al. Cochrane Database Syst. Rev. 8, CD006614 (2021).

    Article  Google Scholar 

  11. Wilson, A. et al. Cochrane Database Syst. Rev. 8, CD014978 (2022).

    Article  PubMed  Google Scholar 

  12. Boughton, S. L., Wilkinson, J. & Bero, L. Cochrane Database Syst. Rev. 6, ED000152 (2021).

    Article  PubMed  Google Scholar 

  13. Roberts, I. et al. BMJ 350, h2463 (2015).

    Article  PubMed  Google Scholar 

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