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The path to destruction for D-type cyclin proteins

The molecular mechanism governing the destruction of key cell-cycle proteins, D-type cyclins, has been elucidated. This mechanism might underlie the lack of response of some human tumours to an inhibitor treatment.
  1. Charupong Saengboonmee

    1. Charupong Saengboonmee is in the Department of Cancer Biology, Dana-Farber Cancer Institute, and in the Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02215, USA; and in the Department of Biochemistry, Faculty of Medicine and Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.

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  2. Piotr Sicinski

    1. Piotr Sicinski is in the Department of Cancer Biology, Dana-Farber Cancer Institute, and in the Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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Proteins called D-type cyclins (cyclin D1, D2 and D3) are key components of the core cell-cycle engine, which drives cellular division. Writing in Nature, Simoneschi et al.1, Chaikovsky et al.2 and Maiani et al.3 provide the long-sought answer to how D-type cyclins are normally degraded.

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Nature 592, 690-691 (2021)

doi: https://doi.org/10.1038/d41586-021-00889-0

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Competing Interests

P.S. has been a consultant at Novartis, Genovis, Guidepoint, The Planning Shop, ORIC Pharmaceuticals, Syros, Cedilla Therapeutics and Exo Therapeutics. His laboratory has received research funding from Novartis.

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