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M4?
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M4
MegaMiracle
Menopause
Moisturizer
A restorative & custom-blended estriol face cream to address signs of aging
$149.97 for a 3-month supply (1.52 oz /45ml)
How it works
Increases collagen production- Retains and restores skin moisture
- Increases skin firmness
- Decreases pore size
- Increases skin elasticity
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Unlimited messaging with a menopause-trained doctorM4 is clinically proven safe and effective
In an independent clinical study, statistically significant improvements seen in M4 Cream compared to placebo in just 12 weeks include:
88%improvement in elasticity
68%improvement in skin health
70%improvement in hydration
57%improvement in skin texture
M4 can be used with or without MHT because it does not impact blood estrogen levels. No changes in serum estriol and estradiol levels.
Read the full clinical studyScience-based ingredients
A note about compounded products
Estriol
Glycerin
Vitamin E
Topical estriol can help maintain skin health by increasing collagen production, retaining and restoring skin moisture, increasing skin firmness, decreasing pore size, and increasing skin elasticity.
Did you know?
Up to 30%
of dermal collagen is lost during the
first 5 years of menopause
and decreases by an additional 2.1% every year after
Who
is it for?
Who is it for?
For any woman—really, any woman—looking to reverse the effects of estrogen-deficiency in the skin due to menopause, perimenopause, or just aging (loss of collagen, decreased elasticity and dryness). M4 works alone or alongside your current menopause treatment plan.
Try it nowHow to use it
Adding M4 once, either to your morning or nighttime skincare routine, is easy. It's safe to use with your other skincare solutions.
During your normal morning skincare routine, apply a pump of M4 to the face and neck when after serums (if you use them). Follow it up with moisturizer, and always complete your morning routine with SPF!
If you're using M4 as part of your nighttime routine, apply a pump of M4 after serums (if you use them), followed by nighttime moisturizers and any retinols (if you use them).
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Related Research
Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. PMID: 33242128; PMCID: PMC7859014.
Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.