Sean Penn compared not being vaccinated to "pointing a gun in somebody's face" as he reiterated his beliefs that the vaccine should be mandatory.
The Mystic River actor referenced the US' 2nd amendment - the right to bear arms - as he discussed the importance of the Covid-19 vaccine.
"It's, you know, I have some areas of strong belief in the Second Amendment,' Penn to host Michael Smerconish," he said in an interview with CNN.
"But I think that you need to recognize how, you know, with something like this, you can't go around pointing a gun in somebody's face, which is what it is when people are unvaccinated."
He also encouraged those who are going to see his new film Flagship to get vaccinated before going to the cinema.
The star revealed he also required everyone on the set of his upcoming show, Gaslit, to be vaccinated.
He told host Michael Smerconish that the usual requirements are that staff who interact with the cast have to get the vaccine.
However, he didn't want to be "complicit" in protecting one group of people and not the rest so he asked everyone to receive the jab.
Sean will return to the set when "100% of the crew" are vaccinated.
The two-time Academy Award winner said those who are unvaccinated fall into two categories.
"'There are those that, once the FDA gives full approval, will go forward with it," he added.
"And that there are those who have become entrenched in a kind of radical libertarianism and an identity of politic that has sort of perversely turned this issue into something that forgets that in the United States of America, our entire history, it's all based on being independent because we understand interdependency.
"The entire history of successful things in this country.'"
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During the Los Angeles premiere of Flag Day, which Sean directed and starred in alongside daughter Dylan, thanked people for being vaccinated.
The film is a crime drama about a daughter’s relationship with her father.
Amid a surge of coronavirus cases caused by the delta variant, those who attended the premiere had to provide proof of vaccination.
Media and security had to provide a negative test before getting to the press area.
Further requirements, as shown in LA's County Department of Public Health guidelines, also include wearing face masks during the entire event.
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