Cycloaddition Reactions at the Beginning of the Third Millennium

Dear Colleagues,

Almost a century after the discovery of the Diels–Alder cycloaddition, this kind of pericyclic process continues to be a very efficient tool in synthetic organic chemistry and shows significant and widespread applications in different chemistry areas, from traditional organic synthesis to medicinal chemistry, materials chemistry, and so on. These reactions are beneficial to chemists because they provide valuable cyclic compounds, often in a simple manner and with high and predictable regio- and stereochemistry in addition to high atom economy. These appealing features make cycloadditions privileged processes in organic synthesis.

In this context, this Special Issue in Reactions aims to collect recent results concerning the applications of [4+2] cycloadditions, namely Diels–Alder, hetero Diels–Alder, and 1,3-dipolar cycloadditions, as well as [2+2] processes. The use of more efficient, green, and sustainable experimental conditions is strongly pursued to improve both the environmental aspects and the synthesis of carbo- and heterocycles with noteworthy applications in the natural, pharmacological, biological, and materials domains.

All researchers working in this field are invited to contribute to this issue emphasizing synthetic and methodological results, as well as mechanistic and/or theoretical aspects. Review articles by experts in the field are also welcome.

Prof. Dr. Donatella Giomi
Prof. Dr. Alberto Brandi
Prof. Dr. Fabrizio Machetti
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reactions is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Diels–alder reactions
• hetero Diels–alder reactions
• 1,3-dipolar cycloadditions
• [2+2]-cycloadditions
• selectivity
• photochemical reactions
• theoretical studies
• atom economy
• sustainable approaches
• heterocycle synthesis