Emerging and Reemerging Infections of the Central Nervous System

Dear Colleagues,

With the contribution of climate and ecological changes, human behaviors and demographics, international travel and commerce, and increased susceptibility of humans to infection, the number of emerging and reemerging infectious diseases is increasing. New clinical syndromes and diseases are constantly arising, either in small, localized outbreaks, or disseminating rapidly to large geographical areas.

In line with the particular sensitivity of the CNS to direct damage by infectious agents or consequent inflammatory responses, almost all recent emerging infections (such as COVID-19, monkeypox, viral hemorrhagic fevers, arthropod-borne virus infection and Nipah, Hendra, and other henipavirus infections) can have neurological manifestations or complications. If, on one hand, neurological manifestations may be present in the acute phase of the disease and even constitute its central syndrome, on the other hand, these may represent late complications and affect populations much later on, with long-term neurological, cognitive, and behavioral consequences.

In CNS infection and due to its high morbidity and mortality, a rapid and efficient response is paramount. However, in the case of emerging infections, scarcity of evidence hampers clinical management. Clinical trials on emerging infectious diseases of the CNS are scarce, and guidelines for its management are often based on experience with case series and by consensus of experts. Hence, the sharing of research findings is critical.

“Emerging and Reemerging Infections of the Central Nervous System”, a Special Issue of Infectious Disease Reports, will collect articles highlighting current knowledge on the epidemiology, pathophysiology, clinical manifestations, diagnostics, and management of emerging and reemerging infections of the CNS.

Original research articles, brief reports, reviews, and case reports are welcome. Essays, opinions, and perspectives are also accepted.

Dr. Sofia R. Valdoleiros
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• emerging communicable diseases
• central nervous system infections
• infectious encephalitis
• meningoencephalitis
• encephalomyelitis