Dynamics of 3D Genome Organization
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 20 August 2024 | Viewed by 19491
Special Issue Editors
Interests: genomics; chromatin structure; transcription regulation; phase separation; epigenetics
Special Issue Information
Dear Colleagues,
Three-dimensional (3D) genome organization provides a physical scaffold and influences all DNA-based biological processes in the nucleus, including RNA transcription, DNA replication, DNA repair, etc. Our understanding of 3D genomes has been deepened by both microscopy- and sequencing-based methods during the past few years and we now know that interphase chromatin in eukaryotic nuclei is folded into multiple layers of hierarchical structures. Recent research has shown that 3D genome organization experiences rearrangement during development, disease and environmental stress, and the dynamics of the 3D genome is important for the progress of these biological processes. In addition, the dynamics of the 3D genome is closely related with the regulation of other epigenetic modifications. More research in the dynamics of the 3D genome organization will not only give us clue for the mechanism of formation and change of chromatin structure but will also deepen our understanding of the roles of the 3D genome. In this Special Issue of Genes, we will highlight the most recent advances in the dynamics of 3D genome organization and its role in various biological process. We are also interested in new experimental and analysis techniques studying chromatin structure. We welcome reviews and original articles in the research area of 3D genome organization.
Dr. Feifei Li
Dr. Xuepeng Chen
Guest Editors
Manuscript Submission Information
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Keywords
- 3D genome organization
- architectural protein
- A/B compartments
- topological associated domain
- DNA loop
- phase separation
- transcription regulation
- epigenome
- new techniques relating to 3D genome
