Research Strategies to Unveil the Genetic and Molecular Basis of ALS
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Technologies and Resources for Genetics".
Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 12907
Special Issue Editors
Interests: neurodegeneration; amyotrophic lateral sclerosis; human genetics; animal models of genetic diseases; zebrafish
Special Issues, Collections and Topics in MDPI journals
Interests: medical genomics; clinical genetics; bioinformatics; amyotrophic lateral sclerosis; developmental disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are delighted to announce a call for submissions to a Special Issue of Genes on the topic “Research strategies to unveil the genetic and molecular basis of ALS”.
Amyotrophic lateral sclerosis is a very complex disease caused by genetic and environmental factors, affecting selectively upper and lower motor neurons.
Genetic causes have been already identified in a subgroup of patients, with pathogenic variants found in a number of genes. Other genes are yet to be identified, although the list of known ALS-associated genes is increasing thanks to the application of novel high-throughput sequencing technologies. The different pathways involved and the pleiotropy of the genes can reflect the clinical heterogeneity observed in patients.
This Special Issue looks to update and advance the current knowledge about genetic causes of ALS, the contribution of predisposing genes, molecular techniques applied to the identification of new genes, and cellular and animal models used to clarify ALS pathogenesis.
Papers providing new insights into ALS genetics and mechanisms and into the relationship between ALS and other neurodegenerative diseases, such as frontotemporal dementia, are welcome.
Please feel free to contact us for any further information about the Special Issue.
Dr. Serena Lattante
Dr. Giuseppe Marangi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- amyotrophic lateral sclerosis (ALS)
- molecular
- genetics
- genomics
- animal models
- cellular models
