Toxics, Volume 12, Issue 6 (June 2024) – 68 articles
Cover Story (view full-size image):
Concern is emerging over organophosphate flame retardants (OPFRs), replacements for brominated flame retardants, for their developmental neurotoxic (DNT) potential due to their ubiquity, structural similarities to organophosphate pesticides and evidence from recent studies. Limited toxicity testing exists on the DNT potential of OPFRs due to challenges accompanying traditional in vivo DNT testing. Here, we employed an integrated approach to testing and assessment (IATA) using an extended battery of DNT in vitro assays and small model organisms that captures cellular processes involved in neurodevelopment and function. DNT potential from OPFRs was then related to human exposure using physiologically based toxicokinetic modeling to provide recommendations for risk assessment. View this paper
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