Photonics, Volume 11, Issue 6 (June 2024) – 100 articles
Cover Story (view full-size image):
Cardiomyocytes are embedded in a complex extracellular matrix (ECM) that includes the basement membrane (BM) and interstitial matrix, which are crucial for maintaining cardiac morphology and function during development and adulthood. Effective tools are essential for analyzing these interactions in freshly dissected tissue and myocardial remodeling. This study used multimodal stimulated emission depletion (STED) microscopy for detailed characterization of the cardiomyocyte microenvironment in myocardial tissue. Paired with second harmonic generation and autofluorescence, the multimodal STED enabled multiplexed 3D imaging of protein distributions. The study revealed subdiffractional structures of the BM and capillaries, while also providing quantitative data on sarcomere length and capillary density, which are critical for assessing myocardial architecture. View this paper
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