Metabolites, Volume 14, Issue 6 (June 2024) – 56 articles
Cover Story (view full-size image):
Microscopic colitis (MC) is an inflammatory disorder of the colonic mucosa that predominantly affects elderly women and causes chronic, non-bloody diarrhea with normal endoscopic findings and normal laboratory values. MC can be divided into collagenous colitis (CC) and lymphocytic colitis (LC). The etiology and pathophysiology of MC are unknown, but smoking shows a clear association with MC. Metabolomic analyses can identify biomarkers that indicate different disease phenotypes, identify risks for developing diseases, and predict responses to therapy. Studies have identified metabolic differences between smokers and non-smokers. Global metabolomics has never been examined in MC patients. The aim of this study was to examine the metabolomic profile of patients to compare the type and course of MC, the presence of IBS-like symptoms, treatment, and smoking. View this paper
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