Antibiotics, Volume 13, Issue 6 (June 2024) – 101 articles
Cover Story (view full-size image):
Carbapenemase-producing Enterobacter cloacae complex strains are increasingly identified in hospital-acquired infections. MLST ST182 has been sporadically reported among Enterobacter hormaechei strains, and recently, outbreaks of blaNDM-producing ST182 clonal strains have emerged. We aimed to investigate the presence of ST182 and explore its evolution and modes of blaNDM acquisition. A phylogenetic analysis of 646 MLST STs identified among 4685 E. hormaechei WGS assemblies deposited in public repositories was performed, as well as in silico comparative and phylogenomic analyses for 55 WGS assemblies of ST182. Our findings showed that ST182 E. hormaechei strains have been identified in the past decade worldwide; 54.5% of them carried diverse blaNDM genetic structures, suggesting the recent acquisition of the blaNDM alleles. View this paper
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