Sensors, Volume 24, Issue 13 (July-1 2024) – 395 articles
Cover Story (view full-size image):
Nucleic acid amplification tests are key tools for the detection and diagnosis of many diseases. While digital amplification offers more precise quantification of target nucleic acids than bulk assays, developing point-of-care (POC) digital nucleic acid tests has been challenging. With the use of the vibrating sharp-tip capillary, a simple and portable system for tunable on-demand droplet generation with a large droplet size range is possible. By combining it with loop-mediated isothermal amplification (LAMP), the requirement for heating elements has also been substantially reduced. This work paves the way for achieving digital nucleic acid amplification tests in resource-limited settings. View this paper
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