Van Andel Institute’s Post

Examine the molecular mechanisms that regulate synaptic development, organization, and function with Matthew B. Dalva, PhD, in the upcoming #MeettheExpert webinar! Register now! ▶️ https://bit.ly/3v8eTZe

I'm very pleased to share our work on the force-controlled release of small molecules with a rotaxane actuator. Published today in Nature thanks to the incredible work of Lei Chen and Robert Nixon! Several force-controlled release molecular systems have been described in the past but they're often limited in the in the diversity and/or quantity of the molecules released per stretching event. We solved this problem by using a rotaxane (an interlocked molecule in which a macrocycle is trapped on a stoppered axle) as a force actuator. This rotaxane device is among the most efficient release systems described to date. We have demonstrated the release of up to 5 cargo per rotaxane, including functional molecules such as a drug, a fluorescent tag, and a catalyst. This rotaxane actuator provides a versatile platform for various force-controlled release applications, and offers great promise for the delivery of drugs and the release of healing or reporting agents in a medical or materials context Read the paper for free here: https://lnkd.in/ecbfG6Rm The University of Manchester

People interested in electromagnetic propagation in lossy materials may also refer to the following papers: Optimized Leaky-Wave Antenna for Hyperthermia in Biological Tissue Theoretical Model (https://lnkd.in/dRaBAguT) Total transmission of inhomogeneous electromagnetic waves at planar interfaces (https://lnkd.in/dd8qfPjf)

I am thrilled to share my latest publication in Lab on a Chip: "Effect of in-plane and out-of-plane bifurcated microfluidic channels on the flow of aggregating red blood cells"! Our research delves into the complex world of blood flow through microvascular systems. By utilizing innovative 3D microfluidic channels excavated in glass, we uncovered how blood behaves differently in non-planar versus planar bifurcations. This could pave the way for more accurate physiological models, enhancing our understanding of blood flow dynamics in the brain. Read More: https://lnkd.in/eEZrzM55 Feel free to reach out if you have any questions or are interested in discussing this further! #Research #Microfluidics #BloodFlow #VascularBiology #ScienceInnovation #LabOnAChip

Featuring one of our September papers published in the IEEE Transactions on Terahertz Science and Technology by Xavier Ramirez Barker, Gonçalo Costa, Rayko Stantchev, Arturo Hernandez Serrano, Gabit Nurumbetov, David Haddleton and Emma Pickwell-MacPherson. This paper presents a sparse deconvolution method to monitor skin hydration under a transdermal drug delivery (TDD) patch with terahertz spectroscopy techniques.  Poly film and woven polyester fiber TDD patches were applied to the subjects’ forearms with propylene glycol for an excipient in three concentrations, and a bare skin location served as the control. Sparse deconvolution was applied to extract meaningful measurements in-vivo with the patch in place. The reconstruction techniques presented in this paper could be applied to accurately control drug delivery by TDD and potentially manage wound healing underneath various medical wraps. Read more here: https://lnkd.in/eM75cMgv

Have you ever wondered how cells move in response to sound waves? 🌫 Researches at Lund University have! In their study, the behavior of suspended cells when exposed to near-zero acoustic contrast was investigated. 🔬 𝗪𝗵𝘆 𝗜𝘀 𝗧𝗵𝗶𝘀 𝗜𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝘁? - 𝗖𝗲𝗹𝗹 𝗦𝗲𝗽𝗮𝗿𝗮𝘁𝗶𝗼𝗻: Understanding cell motion under near-zero acoustic contrast could shed light into new cell separation techniques. - 𝗗𝗶𝗮𝗴𝗻𝗼𝘀𝘁𝗶𝗰𝘀: Improved knowledge of cell behavior informs diagnostic tools and disease detection. 🧪 - 𝗗𝗿𝘂𝗴 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆: Precise control over cell movement aids targeted drug delivery. 💊 🔗 𝗚𝗲𝗦𝗶𝗠’𝘀 𝗖𝗼𝗻𝘁𝗿𝗶𝗯𝘂𝘁𝗶𝗼𝗻: Our expertise in microfluidics and precision instrumentation enabled accurate cell manipulation and observation by fabricating an acoustofluidic glass-silicon-glass chip. If you want to find out what the research found 𝗿𝗲𝗮𝗱 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 𝗽𝗮𝗽𝗲𝗿: 👉 https://lnkd.in/eKGaSb4B #microfluidics #diagnostics #3dcellculture Mahdi Rezayati Charan | Per Augustsson

You can now study weak protein-protein interactions in the micromolar range with #MassPhotometry.

What a timing - immediately after the Brain In Flux meeting in Porto, our preprint got published online. A wonderful collaborative work including Medizinische Universität Wien, Technische Universität Wien, and Florida Atlantic University proposing a ligand coupling mechanism of the human serotonin transporter that distinguishes substrates, partial substrates, and inhibitors! Here’s the link: https://lnkd.in/d7Zrt4dy

Unlock the potential of magnetic beads for biomolecule isolation and purification with Cytiva. Our reliable and innovative methods simplify the process and boost consistency, so you can increase success rates. Read the article to learn how. https://cytiva.link/ilfbf #magneticbeads #diagnostics

Unlock the potential of magnetic beads for biomolecule isolation and purification with Cytiva. Our reliable and innovative methods simplify the process and boost consistency, so you can increase success rates. Read the article to learn how. https://cytiva.link/ilfbf #magneticbeads #diagnostics