UC San Diego’s Post

❗Imagine detecting diseases before patients even show symptoms—it may now be possible with breakthrough MRI technology❗ A new MRI #technology is revolutionizing how we detect diseases at their earliest stages. This cutting-edge method promises to identify #diseases like cancer much earlier than current techniques, potentially saving countless lives through timely intervention. Northeastern University's new QUTE-CE MRI technology transforms traditional #MRI machines, offering non-invasive, high-resolution imaging that could revolutionize #diagnostics. What are your thoughts on the impact of such advancements in #healthcare? Could this be the game-changer we've been waiting for⁉️ Share your insights below and let’s discuss how we can leverage these innovations to improve patient outcomes. 💬 Source: https://hubs.la/Q02FHQjB0. #HealthcareInnovation #EarlyDetection #MedicalBreakthroughs #FutureOfHealthcare #ECRI #NortheasternUniversity

Browse the May issue of eBioMedicine to discover the latest biomedical research we publish at https://lnkd.in/dYy3wmGr This month, we have an insightful editorial summarizing how recent research findings could help improve the management of endometrial cancer: https://lnkd.in/dhMvV77e May’s featured article tests the presence of microplastics in human thrombi across multiple anatomical sites: https://lnkd.in/dWPSrxND We have also highlighted 3 research articles:   ·      Projecting the excess of mortality due to cardiovascular disease attributable to human-induced climate change in the Chinese population by the end of the century:  https://lnkd.in/dtKVBCnu ·      Suggesting a causal link between circadian rhythm disturbance and mood symptoms in patients with major depressive disorder and bipolar disorder based on longitudinally monitored mood symptoms and sleep data with wearable devices: https://lnkd.in/dRWsR2gp ·      Reporting a detailed molecular and histological characterization of cortisol-producing adenomas: https://lnkd.in/dsWDZ-9m And selected 4 more that we think will be of interest to our global readership: ·      Investigating the effects of SNPs in genes encoding alcohol metabolizing enzymes on multiple health domains beyond alcohol-related behaviors: https://lnkd.in/d_cfMFuq ·      Reporting the development of a metric of tau pathology based on neuroimaging data, measuring the extent of tau spatial spread throughout the brain, and its comparison with tau burden in Alzheimer's disease: https://lnkd.in/dR-n-nWj ·      Showing differentially methylated CpG positions in monozygotic twin pairs discordant for Type 2 diabetes: https://lnkd.in/dY556wut ·      Exploring therapeutic mechanisms of PARP inhibitors alternative to DNA damage repair in BRCA1 mutant cancer cells and xenograft tumor mice: https://lnkd.in/d3s6k46i More fascinating research can be found on our website. Please check out the entire issue and enjoy the #openaccess reading!

#ResearchSharing #Paperpublication 💫New Publish... "Minimally invasive thermal therapy is a successful alternative to surgical treatment for local therapy of solid tumors" A recent paper titled "Glycolysis inhibition induces anti-tumor central memory CD8+ T cell differentiation upon combination with microwave ablation therapy" has been published in Nature Communications by Prof. Shui Wang, Prof. Qiang Ding, and Associate Prof. Wenbin Zhou from the Breast Center of Jiangsu Province Hospital (The First Affiliated Hospital of Nanjing Medical University and Jiangsu Women and Children Health Hospital). This study is the first to elucidate the metabolic characteristics of whole-body CD8+ T cells after microwave ablation and discovered that microwave ablation combined with glycolysis inhibitors can induce long-term anti-tumor effects for early-stage solid tumors. This provides a new treatment strategy to prevent recurrence after local treatment of early-stage solid tumors. This study further found that microwave ablation combined with glycolysis inhibitors can enhance the differentiation of tumor-specific CD44hiCD62L+CD8+ TCM cells, thereby producing long-term anti-tumor effects. Mechanistically, the tumor-specific CD8+T cells activated in the tumor-draining lymph nodes migrate out and enter the peripheral circulation during the combined treatment. Read the full article here👇: #MicrowaveAblation  #MinimallyInvasive #GlycolysisInhibition #AntiTumorEffect  #CD8TCells  #Immunotherapy  #CancerResearch

🔬 Exciting Announcement! Our groundbreaking preprint, delves into the intricate world of autoimmune myocarditis. My first-author study employs cutting-edge single-cell technologies to unravel the complexities of immune responses in the heart. 🧬 Autoimmune myocarditis, a complex inflammatory condition, has long puzzled researchers. Through meticulous analysis of tissue samples at various stages of inflammation - acute, subacute, and chronic - we've uncovered fascinating insights into the underlying molecular mechanisms driving this disease. 🔍 Our single-cell RNA sequencing data revealed the presence of T cell-monocyte complexes, particularly pronounced during the acute and subacute phases. These complexes play pivotal roles in signal transduction, immune response modulation, and T cell regulation, shedding light on the dynamic interplay within myocarditis tissue. 📊 Furthermore, our trajectory analysis traced the transformation of macrophages into distinct functional clusters, uncovering key processes like antigen presentation, oxidative stress responses, and phagocytosis. Similarly, our investigation into neutrophil development revealed crucial insights into their maturation and functional stages. 💡 Perhaps most intriguing are our findings on cellular communication networks. We observed phase-specific patterns, including a significant increase in BAFF signaling during the acute phase and upregulation of CHEMERIN signaling in the transition to the chronic phase. 🌟 These discoveries mark a significant leap forward in our understanding of autoimmune myocarditis at the molecular level. 👏 Kudos to the entire team for their dedication and hard work in unraveling the mysteries of autoimmune myocarditis. Together, we're forging new paths towards improved patient care and treatment outcomes. You can find the full paper here https://lnkd.in/dagA847b #single_cell #NGS #Trajectory_Inference

"September 5, 2023 -- Researchers have used MRI to investigate biomarkers that may serve as prognostic markers for individuals with early multiple sclerosis (MS) -- and thus improve patient care and treatment planning. A team led by Vinzenz Fleischer, MD, of University Medical Center of the Johannes Gutenberg University Mainz in Germany, hopes that the study results will help clinicians better understand the disease. Their research was published August 29 in the journal Brain." Continue to read "MRI identifies biomarkers that may predict MS progression" #biomarkers #MRI #MS #callus #vistsus #shoplocal #buylocal #UprightMRIOfDeerfield

Ye W, Chen Q#. Potential Applications and Perspectives of Humanized Mouse Models. Annu Rev Anim Biosci. 2021 Nov 10. doi: 10.1146/annurev-animal-020420-033029. This review discusses the recent advancements and applications of humanised mouse models. Humanised mice with a human immune system and liver humanisation facilitates human disease modelling and translational medicine. Therefore, bridging the translational gap in the development of personalised and targeted disease treatment. Read the article here: https://lnkd.in/d3RzY99f #drugdiscovery #drugdevelopment

I am excited to share that my paper titled “ Noninvasive molecular subtyping of pediatric low-grade glioma with self-supervised transfer learning” is now available on MedRxiv preprint. In this work, we dive deep into developing a first-of-its-kind imaging-based deep learning pipeline that performs the BRAF Mutation classification for pLGG in an automated Scan-to-prediction fashion. Here is a brief look into our work, for more detail checkout the preprint at : https://lnkd.in/enrpMD4t Pediatric low-grade gliomas (pLGG) are prevalent pediatric brain tumors. These tumors exhibit diverse clinical outcomes and molecular characteristics, often driven by an activating BRAF mutation, either the BRAF-V600E point mutation or fusion events. Determining the BRAF Mutational status of pLGG allows for determining prognosis and optimal treatment strategies. Invasive methods are a usual mainstay for such subtyping, but they are not always feasible and may also present serious risks to the patient. We tackle this problem in our work by developing a deep-learning based scan-to-prediction pipeline that performs this classification in a non-invasive manner. The pipeline, being both internally and externally validated, is positioned for clinical translation and experimental usage. Huge thanks to Benjamin H. Kann, M.D. , Zezhong Ye, Ph.D. , Anna Zapaishchykova and all co-authors, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School Excited for the future directions of this work, and even more curious to see further developments in this domain. #Radiology #ArtificialIntelligence #ML #imaging

🌐 The World Health Organization (WHO) recently revised its classification of pituitary tumors, introducing the term "pituitary neuroendocrine tumor" (PitNET) instead of "pituitary adenoma." ✨ Normal and neoplastic adenohypophyseal neuroendocrine cells exhibit similar features to neuroendocrine cells in other organs, both under a microscope and at the molecular level. Additionally, these pituitary neuroendocrine cells express transcription factors that indicate their origin. 🔬 PitNETs can occasionally display aggressive behavior, but the term "pituitary carcinoid" lacks specificity and can either refer to a PitNET or a metastasis from a neuroendocrine tumor. Careful pathological evaluation, along with functional radionuclide imaging if required, helps determine the tumor's origin accurately. 💡 We encourage clinicians to collaborate with patient groups to grasp the terminology used to define primary tumors derived from adenohypophyseal cells. It is essential for responsible clinicians to explain the use of the term "tumor" in a particular clinical context. 📢 #PituitaryTumors #PitNET #NeuroendocrineTumors #WHOclassification #MedicalResearch #Healthcare #Pathology #PatientCare

Beyond the Lab: Understanding the Role of Biomarkers in Modern Medicine. • Liquid Biopsies Revolutionize Cancer Detection • Personalized Medicine Powered by Genomic Biomarkers • Neurological Biomarkers in Mental Health Diagnosis • Inflammatory Biomarkers and Precision Immunotherapy • Cardiac Biomarkers Enhance Cardiovascular Risk Prediction Read more- https://lnkd.in/d53UrjT7  🌐 Follow ProRelix Research : For a continuous stream of exciting developments, informative slides, and expert insights in the dynamic world of Clinical Research! 🌐 📊 #Biomarkers #PrecisionMedicine #MedicalResearch #Diagnostics #MedTech #BiomarkerDiscovery #PersonalizedMedicine #Bioinformatics #HealthScience #Biotechnology #InnovationInMedicine #HealthcareTechnology #FutureOfMedicine #MedicalAdvancements #DiseaseDetection #DigitalHealth

📃Scientific paper: Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis Abstract: Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App ^ NL-F/NL-F and App ^ NL-G-F/NL-G-F , exhibiting AD-like Aβ pathology to analyze how the brain pathologies translate to CSF proteomes by label-free mass spectrometry (MS). This identified several extracellular matrix (ECM) proteins as significantly altered in App knock-in mice. Next, we compared mouse CSF proteomes with previously reported human CSF MS results acquired from patients across the AD spectrum. Intriguingly, the ECM protein decorin was similarly and significantly increased in both App ^ NL-F/NL-F and App ^ NL-G-F/NL-G-F mice, strikingly already at three months of age in the App ^ NL-F/NL-F mice and preclinical AD subjects having abnormal CSF-Aβ42 but normal cognition. Notably, in this group of subjects, CSF-decorin levels positively correlated with CSF-Aβ42 levels indicating that the change in CSF-decorin is associated with early Aβ amyloidosis. Importantly, receiver operating characteristic analysis revealed that CSF-decorin can predict a specific AD subtype having innate immune activation and potential choroid plexus dysfunction in the brain. Consistently, in App ^ NL-F/NL-F mice, increased CSF-decorin correlated with both Aβ plaque load and with decorin levels in choroid plexus. In addition, a low concentration of human Aβ42 induces decorin secretion fr... Discover the rest of the scientific article on es/iode ➡️https://etcse.fr/jwi #alzheimer #science #health