Terry Myerson’s Post

Using propensity matching, below study used real-world data from EHRs to compare weight loss between tirzepatide and semaglutide. Overall, it seems tirzepatide causes more weight loss. In general, weight loss was more effective for both drugs in non-diabetics than diabetics. Also slightly more than half discontinue the drugs at a year due to side effects, with the rate being higher for tirzepatide. Tirzepatide is a different compound than semaglutide, which likely accounts for the difference. It is a receptor agonist (“turns on”) GLP-1 and GIP and is sometimes called a “twincretin” as a result. “Incretins” are compounds/hormones that push beta cells to make insulin. Tirzepatide is essentially a synthetic version of the human GIP hormone. Unlikely we’ll ever get head-to-head trials but this is an interesting way to try and get at that using real world data. It is certainly a clinically plausible conclusion but, strictly speaking, hypothesis generating. At any rate, both drugs work well, and have a role to play in battling diabetes and obesity.

A recent meta-analysis published in "Nature" examined the efficacy of PPIs in treating non-specific chronic cough, revealing a slight reduction in cough severity. This aligns with some previous findings, but contrasts with other studies that showed inconsistent results. Notably, the benefit appears more significant in patients with abnormal reflux confirmed by pH monitoring. This highlights the importance of objective reflux testing before prescribing PPIs, ensuring that only patients likely to benefit from the treatment receive it, thereby optimizing therapeutic outcomes and minimizing unnecessary medication use. Systematic review and meta-analysis: proton pump inhibitors slightly decrease the severity of chronic cough - Scientific Reports https://lnkd.in/gCFN2Fie #reflux #chroniccough #pHtesting #testbeforeyoutreat

Don't miss this important publication, in which well-designed registry-based randomized clinical trial question an old proven 'truth'. Well carried out RWE is essential. https://lnkd.in/dF22XN2k

RESEARCH STUDY FOR PEOPLE WITH MODERATE TO SEVERE ASTHMA Have you or your patients been diagnosed with moderate to severe Asthma? If so, this clinical study is looking for participants between the ages of 18-75 with moderate to severe asthma who have had at least one severe asthma attack in the past year. This study will see how safe and effective the experimental medicine, called amlitelimab, is when used to treat moderate to severe uncontrolled asthma. Learn more: https://lnkd.in/eNwDivhF #sponsored by Sanofi

CVD | CVR | Combined therapy. ❗️Therapies with individual drugs in a combined “network”. 👉Implementation in valuing the use of therapeutic synergies in a metabolic context, ‼️toward personalized medicine.

🔬📚 Exciting News Alert! 📚🔬 🌟 We are thrilled to announce the publication of our latest scientific research investigating the impact of fixed-dose treatments versus free-dose equivalents in the adherence and persistence to pharmacological therapies in patients with hypertension and/or dyslipidaemia! 🌟 📖 Our publication, titled "Impact of single-pill combinations versus free-equivalent combinations on adherence and persistence in patients with hypertension and dyslipidemia: a systematic literature review and meta-analysis," features a comprehensive systematic literature review and a rigorous meta-analysis, providing invaluable insights into optimizing treatment strategies for hypertension management. 💡 👏 A huge thank you to our dedicated team, Petar A., Pauline Le Nouveau, Dr Omar Irfan, and Maryse Kochoedo for their hard work, expertise, and commitment to advancing medical knowledge. This accomplishment would not have been possible without each and every one of you! 🙌 🔍 Curious to learn more? Dive into the full publication here Full article: https://lnkd.in/e6DuQnAa #ScientificResearch #HypertensionManagement #Publication #TeamWork #MedicalAdvancement #HEMA #AmarisHEMA

The Effect of Topical Cow's Milk on the Healing of Diabetic Foot Ulcers: A Randomized Controlled Pilot Clinical Trial (Pub Med). Isfahan University of Medical Sciences. Iran. Published: 2022 Mar 15. Somayeh Shabib 1, Rasool Soltani 1 2, Farzin Khorvash 3, Azade Taheri 4, Mehdi Shahbazi Azad 3 Publication: Int J Low Extrem Wounds 2022 Mar 15;15347346221084788. doi: 10.1177/15347346221084788. Key: #Cow's #Milk #Diabetic #Foot #Ulcer PMID: 35287509 DOI: 10.1177/15347346221084788

Post Ischemia Trial and Clinical Decision Making - 1637070 https://hubs.ly/Q025jqql0

Latin abbreviations are a great way to condense your text. But some scientific and medical authors interchange them or use them incorrectly. Here's a list of common Latin abbreviations, their meanings, and some examples to help you get them right every time: ✍️ cf = compare Example: Although the analysis supports that the drug improves heart rate, several studies reported differences in the drug's effects on hypertension (cf, Smith 2021, Miller 2023). ✍️ eg = for example Example: Patients reported several flu-like symptoms (eg, cough, fever, chills). ✍️ et al = and others Example: Smith et al developed an intervention for patients with breast cancer. ✍️ etc = and so forth Example: The clinician noted signs of a bone fracture (pain, swelling, bruising, etc). ✍️ ie = that is Example: The study identified national acute care or critical access hospitals (ie, nonemergency hospitals). ✍️ vs = versus Example: The researchers compared the effects of the drug on the control vs treatment groups. #medicalwriting #science #medicine

Welcome to read the #published article on our #Pharmaceuticals 😻 "#Thymoquinone: Review of Its Potential in the Treatment of #Neurological Diseases" by Pottoo et al. Enjoy reading: https://lnkd.in/gXv5PvHC