The Francis Crick Institute’s Post

What do increased transposons expression, intron retention, and transcriptional readthrough got to do with aging or senescence? Here is an elegant work by Kamil Pabis et al at NUS Centre for Healthy Longevity and our lab:

So excited to announce my newest series of works titled "Unbearable" that has launched with TAEX curated by Margarita Kuleva! "Unbearable" sets out to live up to the call of author Lidia Yuknavitch to "wreck the wrong world back to life". The project aims to speculatively imagine with technology potential new morphologies for so-called "reproductive" organs when set free from services of breeding. The project aims to not only queer these organs but also re-articulate narratives about their care outside of the framework of their role in reproduction. The work is inspired by my own frustrations as a queer and disabled person dealing with lifelong intensive medical treatments in gynaecology where notions of health and care for my body have had to be dictated by heteronormative assumptions about so-called "female" bodies and the hierarchical value reproduction is given over other biological functions of these organs. It is all-too-often that breeding and reproduction end up both overriding and regulating access to life-saving medical care and treatment. “Unbearable” aims to set loose an unruly and technologically-mediated imagination to explore how these organs could mutate and transform beyond reproductive narratives and the stories history has attached to them. By growing and mutating into something new and other, I seek to question how we can reclaim biological materiality back from determinism and fatalism. These five pieces are available exclusively with TAEX.

Regardless of whether or not one supports this form of research, it is fascinating that the human mind has leaped out-of-the-womb and even out-of-the-gametes scenarios to prove that the web of life can be extended beyond the mechanisms and environments that evolved without human touch. Fascinating. Wow! What will the human species do next? I have yet to read the full article but the abstract is riveting and I also followed up on several science news summaries on this original paper! https://lnkd.in/gcj7UUPM

What reproductive technologies will future humans use in settlements beyond Earth? Bioethicist Dr. Evie Kendal evaluates Artefacts of extraterrestrial communities. One, the Generative Archive, is a strange technology that hints at a planned revolt… Read Extraterrestrial Ectogenesis and join Future Humans in unfamiliar worlds where life is otherwise. https://lnkd.in/eTjVHzhE

🔊 TUNE IN: Our latest episode of #BakerBriefing examines the implications of the recent Alabama ruling on human embryos and takes a closer look at the science of human embryo research. Listen to the conversation between fellows Kirstin RW Matthews, McClain Sampson, PhD, and Edward M. Emmett.

This important study was led by the Telomere-to-Telomere (T2T) Consortium and published in Nature in the paper, "The complete sequence of a human Y chromosome."

☕️ Read this interesting and very important piece on the public perception of #HumanEmbryology and #StemCell #EmbryoModels and the significance of accurate science communication to the public. #sciencecommunication rdcu.be/dr32g https://lnkd.in/eUtB7PMh

In 2003, the Allen Institute launched with just four employees working in a small, rented laboratory toward one audacious goal, driven by founder Paul Allen’s vision - to map the entire mammalian brain in a way the world had never seen. That project, that Allen Mouse Brain Atlas, became a hallmark for the way the Allen Institute works — cohesive teams tackling big problems in biology and sharing their findings openly to benefit all of science and humanity. Today, 20 years later, the Allen Institute is building foundations and reaching new frontiers in our quest to fully understand the brain, the cell, and the immune system. Explore our history of impact at https://lnkd.in/g6Dge3cD. #OpenScienceWeek #OpenScienceDay #Allen20

Human-centric approaches such as microphysiological systems and in silico methods have shown great promise in developing our understanding of human biology and disease, but can the use of these novel methods be wholly embraced within a prevailing research paradigm that has been both built upon and dominated by animal models? https://lnkd.in/gDH9Cd5Q Read the full article:

Congrats Matthew Wall, Eugenii A. (Ilan) Rabiner and colleagues on this insightful publication! Explore the role of neuroimaging technology in the understanding and development of psychedelic therapies and what the future may hold: https://lnkd.in/eaS9K3t8