The Francis Crick Institute’s Post

Our new publication on cancer gene fusions highlight a novel way in which fusion genes can be aberrantly activated. The work highlights the intricate way in which the underlying genome organization might influence this activation. https://lnkd.in/gmmM6ZJn

I am happy our latest and my first author Publication provides valuable insights into the differential expression patterns of miRNA-4716-3p, the AKT2 gene, and its genetic polymorphism (rs2304186) in Pakistani blood cancer patients. https://lnkd.in/dduJgHd7

#SOD1 In a recent study published in the journal #Cancer Gene Therapy, a team of researchers from China and the UK was able to reduce the growth of cisplatin-resistant tumors in female mice by decreasing the activity of a gene called superoxide dismutase 1 (SOD1). This finding could potentially increase the #ovariancancer survival rate! Read here: https://lnkd.in/eFWrbFp6

Ahead of print Profiling of microRNA as a tool to introduce rAAV vectors in gene therapy of breast cancer: A preliminary report Despite the wide range of diagnostic and therapeutic methods, breast cancer is responsible for many deaths each year. One of the original and novel cancer therapeutic approaches is gene therapy based on recombinant adeno-associated viral vectors. Among the molecular factors with the potential to become useful diagnostic biomarkers, microRNA (miRNA) molecules are being considered for personalized therapies. The aim of the study was to examine the utility of miRNA profiling in the design of personalized recombinant adeno-associated virus (rAAV)-based gene therapy for breast cancer patients. https://lnkd.in/drnHVeFc

In BRCA gene mutation carrier cells, the defect of liganded ER activation is the initiator of DNA damage and cancer development

Explore the frontiers of biomanufacturing in this comprehensive webinar, Advances in viral vector gene delivery for cell therapy biomanufacturing, where leading experts from the field share insights on recent advancements in viral vector gene delivery. Join our speakers as they provide a foundational understanding of various vector types, such as lentiviruses, adeno-associated viruses (AAV), and retroviruses, and their respective roles in gene delivery. The webinar will then address recent technological advancements in viral vector manufacturing and explore quality control measures necessary for safety. Join us for an informative webinar featuring Daniel Stone (Fred Hutchinson Cancer Research Center), Xiuyan Wang (MSSC), and Steven Feldman (Stanford University) and moderated by Mohamed Abou-el-Enein (USC) and Gerhard Bauer (Independent Consultant). These renowned experts will discuss the latest advancements in cell therapy and viral vector gene delivery, offering a unique perspective on the current trends and future potential of biomanufacturing. Registration is free, the discussion starts at February 1, 12:00 pm ET. https://hubs.li/Q02g7T5G0

RET gene mutations are involved in the development of medullary thyroid cancer. Identifying the RET gene can impact patient treatment as well as help patients and their families. Is genetic testing being underutilized? Read the research. http://ow.ly/q8UR50NuirY #oncology #CancerResearch #genetherapy

This work presents the history of the recognition of principal gene regulatory capacities of estrogen hormones having been mistakenly regarded as breast cancer promoting agents for more than 120 years

Are bispecific RNAs a promising approach to treat diseases? _ a double stranded RNA (dsRNA, siRNA) that activates one gene and knocks down another one simultaneously. Simultaneous (a) #activation of RIG-I gene and (b) #knockdown of PLK1, using a single antibody-siRNA molecule. RIG-I recognizes the dsRNA (activation) and triggers the expression of interferons and pro-inflammatory cytokines, inducing an inflammation of the tumor environment and activating neighboring immune cells. Simultaneously, siRNA-mediated PLK1 knockdown (silencing) promotes cancer cell death by apoptosis. #bispecificRNA , #bispecificRNAs #doublestrandedRNA , #dsRNA #geneexpression #genesilencing #siRNA #RNAi , #RNAinterference #RNAtherapeutics #Oligonucleotides #targetedtherapy #targetedDelivery . https://lnkd.in/dk4xBhEZ