First-line nab-paclitaxel plus carboplatin for patients with advanced non-small cell lung cancer: Final results of the NEPTUN study.
What's new?
Non-small cell lung cancer (NSCLC) patients often are diagnosed in advanced stages of disease, at which point, in cases without targetable mutations, first-line therapy typically entails platinum-based chemotherapy. A recommended therapy is albumin-bound paclitaxel plus carboplatin combination (nab-P/C). Here, the authors evaluated the use of first-line nab-P/C therapy in a real-world setting in patients with locally advanced or metastatic NSCLC. Results show that survival was improved among nab-P/C-treated patients, with better outcomes observed particularly among patients age 70 and older and in those with mild to moderate renal impairment. Improvements in tumor response, independent of histological subtype, were also observed.
Dechow T, Riera-Knorrenschild J, Hackanson B, Janssen J, Schulz H, Oppermann U, Chiabudini M, von Weikersthal LF, Budweiser S, Nacke A, Taeuscher D, Welslau M, Potthoff K. Int J Cancer. 2023 Jul 1;153(1):141-152. doi: 10.1002/ijc.34467. Epub 2023 Mar 8.
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Picture with courtesy of the National Cancer Institute
CEO @ATLASOncology: Inst for Pancreas Liver and Advanced Cancer Ablation// SurgicalOncologist@Memorial Hospital//SurgOncDir@Donoway Center for Cancer Treatment and Prevention / CEO@Expert Med Consultants
3wThank you. When studying any area we always go back to the breast cancer arena to learn so much of where we need to be prepared to focus attention; Especially in Pancreas, ever since the BRCA2 connection was made. Again thank you!