Seer’s Post

Committing to Revolutionizing Proteomics, SomaLogics Groundbreaking SomaScan 11K Platform has been announced. The platform enables the measurement of half of the human #proteome from a single sample with exquisite specificity and reproducibility, increasing the protein measurements across major disease pathways for broader discoveries. #cardiology #inflammation #neurology #oncology #proteomics #ashg2023

🔹Researchers have made a significant advance in neuroscience by developing for the first time 3D models of the brain, known as chimeroids, that incorporate cells from various human donors. This innovative technique could transform our understanding of the diversity of brain responses to medications by simulating how different genetics influence reactions to therapies. Scientists hope to better predict the effects of drug treatments before their use in clinical trials, offering an invaluable tool for personalized medicine and the study of neurological disorders. Read the full news here 👉🏼 https://lnkd.in/dri97Xgw #techtitute #medicine #neurology #drugs

A recent study in Nature Aging by Betty Tijms and Pieter Jelle Visser at the Amsterdam UMC - Alzheimer Center Amsterdam has identified 5 distinctive Alzheimer's disease (AD) subtypes through an analysis of cerebrospinal brain fluid (CSF) proteomics in a large dataset of AD patients versus controls. What's more, each subtype was linked to specific genetic risk factors and differed in cortical atrophy patterns and survival times, emphasizing their clinical relevance. These findings represent a step towards personalized medicine in neuroscience and identifying the right patient for the right drug. This could be especially relevant for a few drugs currently in development, for example antibodies and small molecules targeting TREM2 and CSF1R. https://lnkd.in/edxQfJmX #neuroscience #alzheimersdisease #healthcare #medicine #science

Ever wonder why people respond differently to the same drugs? 🧠🔬 Exciting news in brain research might have the answer. Researchers have developed 3D brain models, called Chimeroids, that include a variety of cell types from multiple donors. These "𝐯𝐢𝐥𝐥𝐚𝐠𝐞 𝐢𝐧 𝐚 𝐝𝐢𝐬𝐡" organoids could help us understand individual differences in drug responses and brain development, paving the way for personalized medicine. While past efforts produced 2D sheets of brain cells from multiple donors, these new 3D models are a game-changer. By combining cells from up to five donors, and potentially hundreds in the future, Chimeroids can help predict individual responses to new treatments before clinical trials. The breakthrough involved first creating single-donor organoids and then merging them to form a composite organoid. These Chimeroids, which grow to about 3-5 millimeters, mimic fetal cortical tissue and could revolutionize how we study brain diseases and drug effects. Although growing Chimeroids is labor-intensive, automated cell-culture systems are on the horizon, which will make these models more accessible for widespread research. #Neuroscience #Organoids #BrainResearch #PersonalizedMedicine #Innovation

Unveiling Oligodendrocyte Secrets & Aging Insights New multi-omic identifies RNA and chromatin changes during aging. Here I will summarise what happens in oligodendrocytes, the brain cells responsible for insulating neuron connections, since probably more posts will describe this study. The authors developed a new multiomics method which revealed that oligodendrocytes and other cortical cells undergo significant changes during aging. Astonishingly, oligodendrocytes demonstrate distinct interaction patterns compared to other cell types, hinting at their unique role in brain aging and diseases like Alzheimer's. The study shows that oligodendrocytes exhibit fewer short-range chromatin interactions in older brains, correlating with both agsing and Alzheimer’s pathology. This decrease in interactions suggests a deterioration in cellular communication and function, potentially impacting cognitive abilities. 🔬#Neurobiology #Ageing #Oligodendrocytes #AlzheimersResearch #BrainHealth #WomenInScience #Innovation #MultiOmics Source: https://lnkd.in/ekXGGAKE

🎉 Excited to share my achievement! 📚 Published a research paper in Molecular Neurobiology titled: "Microglial Neuroinflammation-Independent Reversal of Demyelination of Corpus Callosum by Arsenic in a Cuprizone-Induced Demyelinating Mouse Model." 🧠💡 Delving into the fascinating world of molecular neurobiology, our study sheds light on the potential role of arsenic in reversing demyelination, offering insights into innovative therapeutic avenues. Grateful for the collaboration and support from my team, mentors, and the scientific community throughout this journey. Looking forward to further exploration in this field! 🌟 #Research #Neurobiology #Publication #Science #molecularbiology #toxicology

Uridine as a rejuvenating strategy for hematopoietic stem in mice A recent Nature Aging study https://lnkd.in/epUmBpxa entitled: "A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells" explored age-related metabolic shifts in murine hematopoietic stem and progenitor cells (HSPCs). Metabolomic profiling revealed enrichment of purine, pyrimidine, and retinol metabolism in young HSPCs, while aged cells exhibited increased glutamate and sphingolipids pathways. Uridine treatment emerged as a potential rejuvenating strategy, promoting self-renewal and FoxO pathway upregulation while suppressing inflammation in aged HSPCs. Furthermore, the study established an open-source platform for blood cell metabolomic analysis, a valuable tool for future investigations. #genetics #genomics #precisionmedicine #genomicmedicine #brain #neurology #neurodegeneration #blood #stemcells #aging #longevity #inflammation #sphingolipids #omics #metabolomics #metabolome #metabolism #health #biomarkers #therapeutics #biotechnology #innovation #research #science #sciencecommunication

Recent progress in chemistry, molecular and cell biology, and nanotechnology has expanded the strength of #MRI to characterize pathological tissue changes by providing tools that visualize cellular and molecular processes. A wealth of novel imaging probes, reporter gene - and cell-labelling strategies provide the basis for gaining unprecedented insight into the pathomechanisms of neurological disorders. Here, we illustrate examples from academic research groups’ work on the application of molecular and cellular MRI in models of neurological disorders and its use for the evaluation of gene and cell therapies. Download the paper here: https://lnkd.in/dq52PX3W Please visit us at booth C08 at the ISMRM Conference on May 4-9 in Singapore to learn more about Bruker's MRI solutions: https://lnkd.in/d4YvbZvS #ISMRM #ISMRM2024 #Imaging #PreclinicalImaging #Neurology