Scribe Therapeutics’ Post

Adenine base editors, such as ABE7.10, enable programmable C•G to T•A point mutations, but editing efficiencies can be low at challenging loci in primary human cells. 🧬 Discover how Beam Therapeutics leveraged DNA variant libraries of adenine base editors, synthesized by Ranomics, to evolve ABE7.10 into the ABE8s with superior editing performance 👉 https://lnkd.in/gAJCq7TJ #beamtherapeutics #crisprcas9 #geneediting #genetherapy #geneticengineering #dna

🔬🎯 Elevate Your Drug Discovery With NorthEast BioLab: Explore Our In-Vitro Target Validation Service, Meticulously Crafted To Enhance Drug Efficacy And Unlock New Therapeutic Frontiers. Discover Our Dynamic Suite Of Capabilities: 🧫 Custom Cell Line Development: Harness Specific Reporters Or Tags For Incisive Drug-Target Interaction Insights. 🧪 Advanced Transfection Techniques: Employ Our Sophisticated Plasmid And Viral Transfections For Top-Tier Cell Line Research. 🔎Potency And Selectivity Optimization: Bolster Your Therapeutic Development With Pinpointed Affinity And Cellular Penetration. 🧬 Comprehensive Molecular Biology Suite: Delve Into Gene Cloning, Exact Site-Directed Mutagenesis, Expansive cDNA Libraries, And Targeted siRNA Knockdowns  💡 Speak To Our Scientists Today to fast-track your drug development process.  https://lnkd.in/dw2ra3KM #DrugDiscovery #DrugDevelopment #CellBiology #MolecularBiology #CellBasedAssay

#OrigiGator Genascence Corporation, a clinical-stage #biotech company, announced the Phase 1 #clinicaltrial data for its osteoarthritis treatment at the European Society of Gene and Cell Therapy 30th Annual Congress. 🧬 They were able to demonstrate that the drug met the primary safety endpoint and was well-tolerated in all study subjects. They also noted encouraging symptomatic improvements! 📈 This is the first step for bringing the tech, licensed from University of Florida College of Medicine's Dr. Steven Ghivizzani, to market. 💉 Learn more, here. ▶️ https://lnkd.in/erdyD-_U

A few hours left before the webinar, where you can learn how genomics combined with proteomics at population-scale is transforming our understanding of disease biology and accelerating more effective drug development. Dr. Ryan Dhindsa will share findings from an ambitious project to map the influence of rare gene variants on the levels of almost 3,000 proteins measured in plasma from over 50,000 participants in the UK Biobank Pharma Proteomics Project. He will show the vital role played by rare variants in the regulation of the human proteome and discuss the implications for biomedical research and future healthcare. Register here: https://bit.ly/3UFuJno #proteomics #biomarkers #precisionmedicine #drugdevelopment

Clustered regularly interspaced short palindromic repeat (CRISPR)- Cas9 system is a breakthrough genetic engineering technology. This advanced-level course is designed to develop an understanding of complex concepts related to genomics, particularly CRISPR/Cas technology and its applications in drug discovery, therapeutics and much more. Learn more https://lnkd.in/grHX4cq

Looking forward to #SLAS2024 where we will be showcasing our ioCRISPR-Ready Cells™️ products. Our poster presentations will include data from two products - the recently launched CRISPR-Ready ioGlutamatergic Neurons™️ and the next product in the range - CRISPR-Ready ioMicroglia™️. Find out more in the press release. 👇📰 https://hubs.ly/Q02j60Vz0 ioCRISPR-Ready Cells are iPSC-derived human cells containing a constitutively-expressed Cas9 nuclease. They arrive ready-to-use and with simple protocols, allowing high gene knockout efficiencies and functional experimental readouts in a physiological relevant cellular model in days, significantly reducing experimental timelines. #CRISPR #Research #DrugDevelopment #SynBio #BioEngineering

Thanks to Adrian Keatinge-Clay and his lab at The University of Texas at Austin for sharing the challenges of high complexity, #longDNA PKS (polyketide synthases) gene cluster synthesis! The Keatinge-Clay lab joined ELEGEN's Early Access Program, where they ordered the de novo synthesis of a 14,713bp plasmid containing a complex PKS gene cluster. Elegen delivered, shaving off 1-2 wks of time and labor. “With Elegen’s ability to synthesize regions of high complexity, the Keatinge-Clay lab is able to move projects with difficult, complex sequences, including repetitive GC-rich regions, from the drawing board to the incubators in a matter of weeks.” Read the case study: https://bit.ly/3U5Ma1H #plasmidsynthesis #SyntheticDNA #synbio #DNA innovation #EnfiniaDNA

Our focus on #innovation will not be shaken! If you are onsite at the European Society of Gene and Cell Therapy Congress, head to the Gale Maritime Room to check out Heiko von der Leyen representing the team by presenting our poster P353: A concept of decentralized point-of care manufacturing of #cellandgenetherapy – #technical and #regulatory considerations.

The genedrive team are all set up and looking forward to meeting you ESPT Congress in Copenhagen. Visit stand 3 to hear how the Genedrive® ID Kits are being used to guide treatment in time critical situations.    By providing automated result of CYP2C19 genotypes to inform clinicians on an individual’s metaboliser status; and by reducing the risk of aminoglycoside induced hearing loss (AIHL) by detecting a variant in the MT-RNR1 gene (m.1555A>G). #GDR #pharmacogenetics #pharmacogenomics #ivdr #poc #personalizedmedicine #espt2023 #CYP2C19

📰 Pectins and The Health Effects 🔍 Pectin, a #plant -derived polysaccharide, possesses #\immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. #cancer #cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. 👨🎓 Lucas de Freitas Pedrosa, Karen Rebouças Nascimento, Caroline Giacomelli Soares, et al. 🔗 https://lnkd.in/gDiE48jt Plants MDPI Plant Based News 👇 Figure 1. Schematic depiction of variable pectin molecules and their respective region of higher biological activity.