Sciforum’s Post

🔬 𝐄𝐱𝐜𝐢𝐭𝐢𝐧𝐠 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐀𝐥𝐞𝐫𝐭 Heartfelt congratulations on the recent publication of your paper! This research delves into the milligram-scale enantioresolution of promethazine and its main metabolites, offering valuable insights into their absolute configuration and enantioselective effects on human SY-SY5Y cells. The authors discuss the importance of understanding the enantioselectivity of promethazine (PMZ) and its metabolites in relation to toxicity, particularly in the context of drug abuse. Using chromatography techniques, the study achieves enantioseparation of (R,S)-PMZ and its metabolites and determine their absolute configuration for the first time. Cytotoxicity studies on human neuroblastoma cells show significant differences in toxicity between the enantiomers, underlining the importance of isolating enantiomers for toxicity studies. Overall, the study underscores the importance of enantioresolution for assessing drug safety and efficacy, particularly in overdose scenarios, and highlights potential neurotoxic effects of (R,S)-PMZ and its metabolite (R,S)-DMPMZ. Thank you for choosing the SCHMIDT + HAENSCH Polartronic Universal polarimeter for this study. It was used to determine the optical rotation of the enantiomers of DMPMZ at ± 19 ◦C. It allowed the measurement of the optical rotation values, which provided insights into the stereochemistry of the molecules studied. The volume of the measuring cell was 1 mL, the optical path length was 10 cm, and the solvent was EtOH. We look forward to seeing how your research advances our understanding of active pharmaceutical compounds and their impact on human health.   Here you can find the paper: https://buff.ly/3WCpDuN Here you can find our Polartronic V: https://buff.ly/47VnIUg #SchmidtHaensch #Research #Polarimeter

SEMINAR ALERT: Analytica pharma day 2024 by SCIEX FUELING YOUR ANALYTICAL WORKFLOWS WITH SCIENCE April 10, 2024 | 3:00 p.m.–5:00 p.m. CET Location: Conference room A32, Hall A3, Messe München Trade-Fair Center, Munich REGISTER: https://lnkd.in/dmXWaT7n The SCIEX and Phenomenex teams have been working and learning with our CUSTOMERS for answering the questions they might have in what concerns to the drug discovery and drug development of drugs. Now we want to share all the science we´ve understood with all the people attending to ANALYTICA. Here you have the topics we will cover: 15:00 – 15:30. Unveiling the latest HTS technology 15:30 – 16:00. Nitrosamines in drug products: overcoming sample preparation challenges via SPE for simultaneous quantification of 13 n-nitrosamines in various drugs 16:00 – 16:30. Analytical insights into nitrosamine drug substance related impurities (NDSRIs) 16:30 – 17:00. Structural elucidation of conjugation drug metabolites by utilizing novel electron-activated dissociation (EAD) Thanks to our speakers, Kristin Von Czapiewski, Heiko Behr and Axel Besa After the meeting you can join the Danaher Corporation booth where we´re sharing knowledge and experiences and some refreshments together with Phenomenex, Leica Microsystems and Beckman Coulter Life Sciences... and more! #lcms #pharmaceuticalindustry #drugdiscovery #drugdevelopment #hts #highthroughputscreening #drugmetabolites #drugmetabolism #drugcatabolism #metid #metabolitecharacterization #glucoronides #acylglucoronides #impurityprofiling #drugimpurities #ndsri #nitrosamine #qqq #qtof #hrms #ead #zenotof #triplequad #sciex #phenomenex

𝗘𝘅𝗰𝗶𝗣𝗲𝗿𝗶𝗲𝗻𝗰𝗲 𝟮𝟬𝟮𝟯 - 𝗗𝗮𝘆 𝟮 𝗶𝘀 𝘀𝘁𝗮𝗿𝘁𝗶𝗻𝗴 𝘀𝗼𝗼𝗻! After a first day full of science and networking we are moving ahead soon. Join in again and enjoy the packed program with A new and sustainable microcrystalline cellulose Kalle Riihinen, Nordic Bioproducts Group Microneedles: Tiny structures with big potential Prof. Ryan F. Donnelly A Journey into the Wonderful World of Emerging Pharmaceutical & Biopharmaceutical Technologies Prof. Dimitrios A. Lamprou Machine learning approaches to the prediction of powder flow behaviour of pharmaceutical materials from physical properties Laura Pereira Díaz Selecting Excipients for Improved Drug Palatability David Tisi Radically simplifying individualized treatments Jonas Bäck, Ondosis Templated inverted particles (TIP) as a novel pharmaceutical excipient Prof. Dr. Jörg Huwyler, Galvita TaBlitz: Globally Revolutionizing Tablet Design Casey Davis, Tablitz Formulation and Delivery of RNA Vaccines: The Carrier is Key Prof. Camilla Foged Risk approach Excipients Janeen Skutnik-Wilkinson Join the event here: https://lnkd.in/ddbsjM94 #excipients #drugdelivery #pharmaceuticals

Check out our recent paper entitled ‘Development of a buccal in vitro permeation method – exploring aQbD implementation’, published in the International Journal of Pharmaceutics!!!!

We had the pleasure of presenting a #poster at the Applied Pharmaceutical Analysis conference earlier this week on the deconvolution of multiple population distributions within a dataset to calculate cut points specific to sub-populations. The poster presented proof-of-concept, and we will now work toward answering the questions about how to decide which cut points should be used. Please stay tuned for future updates! #immunogenicity #bioanalysis #drugdevelopment

⭐ BIO Notebook Day 3: Amgen CEO Blasts IRA, Novo Nordisk Stays Cautious On BD, And More •Who should read this? Pharma and biotech decision-makers – including CEOs, BD&L, strategic intelligence/competitive intelligence, medical, and regulatory/compliance. •What is it? One installment of Scrip’s daily notebook of noteworthy intelligence from the BIO International Convention in San Diego. •Why is it important? BIO is a key industry conference, and Citeline Insights has five reporters covering the event live on the ground. Our writers share key highlights each day, moderate sessions, and write up interviews and features over the coming days. This article highlights Novo Nordisk’s philosophy around spending its GLP-1 windfall on business development. Citeline Citeline Commercial #BIO2024

Last week, our colleague Norbert Klapper was at the #DGTI Congress, the 56th Annual Congress of the German Society for Transfusion Medicine and Immunohaematology in Berlin. An important event for us and a forum for scientific discussions and networking. The focus of our booth was our Sigma 8KBS blood bank centrifuge. The refrigerated floor-standing centrifuge has been specifically developed for use in blood banks and transfusion facilities and is a medical device as defined by the new EU Regulation 2017/745. #laboratoryequipment #lab #medizintechnik #medizin #medicaltechnology #medicine #medtech #laboratory #pharmaceuticalproduction #pharma #biotechnologie #biotech #pharmaceutical #lifesciences #medicaldevices #science #centrifuges #health #quality #research #sciencenews #innovation #lifescience 

SFBN Feed: Horizon, Roche top list for pharma reputation among rare disease patient groups, survey finds https://lnkd.in/gdNv8DUR As rare disease drug research increases among large pharma companies, so do their reputations with rare disease patient groups. The latest survey in PatientView’s annual research found that 57% of patient advocates say the pharma [...] #BayArea #SanFrancisco #Biotech #Lifescience #News

Don’t miss our Principal Scientist, Jing Liu’s poster presentation on Tuesday, May 7th at this year’s #WRIB event in San Antonio. Key learnings from Jing’s presentation will be: • Self-assembling drug XPro159 is challenging for standard ADA format like Bridging or ACE • Presentation of a novel format, ACE-AG, designed to solve the problem • The format mitigated the high background from the self-assembly of the drug and provided excellent sensitivity. It also demonstrated drug tolerance and robustness against endogenous target interference. Want to set up a time to meet at WRIB or if you’re not attending and want to chat, just click here: https://bit.ly/3Uuv6lQ #drugmetabolism #pharmacokinetics #lifescience #invitro #biotransformation #dmpk #pharma #biotech #research #drugdevelopment #bioanalysis #bioanalytical #immunoassay #lcmsms #lcms #hrms #pharma #adme #oligonucleotides #monoclonalantibodies #rnabasedtherapeutics

🌿 Explore the therapeutic potential of Chrysin, a natural flavonoid! 🌿 This highly cited article provides a comprehensive review of its wide-ranging benefits, molecular targets, and bio-pharmaceutical aspects. Discover Chrysin research! 🧪 https://ow.ly/1SCi50Qj0VX 📚 Author(s): Anuj Garg* and Shashank Chaturvedi #Research #Pharmacology #BenthamScience