Brooke M. Emerling, Ph.D., is contributing to a revival of interest in an underappreciated set of enzymes called phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). Emerling and team have now shown for the first time that PI5P4K activity is connected to the regulation of an ancient signaling system called the hippo pathway, which is found in a wide variety of organisms and is known to help human organs grow and control their size. In a study published in Science Signaling, Emerling and co-senior author Raymond Blind, Ph.D., at Vanderbilt University Medical Center, shared their findings, which open new research avenues to tackle aggressive cancers. Read more: https://bit.ly/3Vhg3wh #enzymes #PI5P4K #cancerresearch
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The Rally Foundation for Childhood Cancer Research has awarded Ani Deshpande a grant in support of his work to help find a cure for childhood cancer, part of the $5 million in research grants distributed by the Rally Foundation and its Collaborative Partners this year. For a full list of the 2024 grants, https://lnkd.in/eH_NeTT8 #RallyOn #GOLDSTRONG
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The San Diego Nathan Shock Center is accepting applications for its Pilot Grant program. Scientists interested in studying the biology of aging can receive up to $20,000 ($50,000 for spatial-omics or longitudinal single-cell studies) for services, supplies, training workshops and travel to San Diego. Applications are due August 22, 2024. For more information on eligibility, application requirements and to apply, visit https://bit.ly/3B5VVjU #grantopportunity #researchfunding #sciencefunding #grants Salk Institute for Biological Studies, UC San Diego
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Congratulations to Aryaman Bhattacharya who won The Lee Summer Student Fellowship! Recently graduated from the BS/MS contiguous program in Biology at UCSD, Aryaman will now transition to his master’s in Debanjan Dhar’s lab at Sanford Burnham Prebys. Aryaman will study if inhibiting Ubiquitin D confers protective effects against alcoholic liver disease, which could pave the way for new therapeutic approaches to treat ALD and related liver disorders—including cancer. The Fellowship is given by the Southern California Center of ALPD and Cirrhosis within the Keck School of Medicine of USC. More: https://lnkd.in/gfXYpUbD
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David Brenner’s latest essay for The San Diego Union-Tribune’s Community Voices Project is now live. “𝐎𝐩𝐢𝐧𝐢𝐨𝐧: 𝐓𝐡𝐞𝐫𝐞’𝐬 𝐚 𝐬𝐞𝐜𝐫𝐞𝐭 𝐭𝐨 𝐥𝐢𝐯𝐢𝐧𝐠 𝐥𝐨𝐧𝐠 𝐚𝐧𝐝 𝐡𝐞𝐚𝐥𝐭𝐡𝐲," describes how living a vigorous life: walking, gardening and enjoying sex well into the golden years, can lead to a longer well-lived life. Read the full article here: https://bit.ly/3VCsi5D.
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Sanford Burnham Prebys recognized the beginning of Pride month with a Pride flag-raising event on Friday, June 7, 2024. The gathering included an opportunity for speakers in a variety of roles throughout the Institute to share comments on the meaning of the Pride flag in their lives and careers. 🏳️🌈 David Brenner, M.D., president, CEO and Donald Bren Chief Executive Chair at Sanford Burnham Prebys, opened the ceremony, saying, “I’m very proud of everyone for working together to make this a welcoming community.” Alessandra (Lale) Cecchini, Ph.D., postdoctoral associate in the lab of Alessandra Sacco, Ph.D., concluded the formal ceremony, reflecting, “This gesture speaks loudly about who we are and what we stand for in terms of valuing acceptance, unity, respect and kindness.” She added, “While we have come a long way, we still have further to go. I hope this and other diversity-related events on campus encourage you to feel safe and empowered to fully be yourself.” Learn more about the event: https://bit.ly/4bU4UXX #pride #pridemonth #dei #deib #diversity #equity #inclusion #belonging
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🎓❤️ On Friday, May 31, 2024, the Sanford Burnham Prebys Graduate School of Biomedical Sciences hosted four graduates, their family members and friends as well as current students, faculty members and staff at the Institute’s campus in La Jolla for the school’s first-ever Commencement ceremony. In addition to honoring the four graduates in attendance, the event also recognized the 62 other alumni who graduated from the Institute’s graduate school in the nearly 20 years since its founding in 2006. “The faculty and community at Sanford Burnham Prebys have been tremendous and afforded me the most meaningful opportunities to learn and grow,” said Stephen Sakuma, Ph.D. ’24, during his speech on behalf of Sanford Burnham Prebys alumni. “The journey has been long and, at times, arduous, but it also has been exceedingly rewarding.” Read more: https://bit.ly/3yWww0f #graduateschool #scientificresearch 📸 Pictured from left to right are Rachael McVicar, Ph.D. ’23; James Kent, Ph.D. ’22; Monica Gonzalez Ramirez, Ph.D. ’18; and Stephen Sakuma, Ph.D. ’24.
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Congratulations to Chiara Nicoletti, Ph.D., one of three winners of the Young Investigators Award at the 2024 Dysferlin Conference organized by Jain Foundation Inc. Nicoletti, a member of the Puri laboratory at Sanford Burnham Prebys, played a crucial role in analyzing and characterizing single-cell and single-nucleus gene expression in dysferlin-deficient muscle, a challenging task given the wide breadth of data. Nicoletti's efforts have led to a deepened understanding of #dysferlinopathy, a group of inherited muscle diseases characterized by progressive muscle weakness and atrophy. The conditions, for which there are no treatments or cures, are caused by a mutation in the gene that makes #dysferlin, which is important for efficient muscle repair.
We congratulate the winners of the Young Investigators Awards from the 2024 Dysferlin Conference. Alastair Khodabukus, Ph.D.,laboratory of Prof. Nenad Bursac, Duke University—Ali was instrumental in developing techniques for growing functional myobundles from iPS cells, and for characterizing and investigating several phenotypic abnormalities in dysferlin-deficient myobundles, involving calcium handling, cholesterol homeostasis, and metabolism. His work has yielded new insights into the function of dysferlin and identified potential treatment approaches. Stacey Nicole Keenan, Ph.D., laboratory of Prof. Matthew Watt, University of Melbourne—Stacey’s work has led to the identification and characterization of the extensive changes in lipid composition, storage, metabolism, and regulation that occur in muscle as a result of dysferlin deficiency. This work has shown the lipid abnormalities to be a distinctive key feature of dysferlinopathy, rather than a nonspecific downstream effect, raising potential therapeutic targets. Chiara Nicoletti, Ph.D., laboratory of Prof. Lorenzo Puri, Sanford Burnham Prebys Medical Discovery Institute—Chiara has played a leading role in data analysis in an ambitious undertaking involving three research groups to characterize single cell- and single nucleus gene expression in dysferlin deficient muscle. It has been known that in dysferlin deficiency there are large numbers of inflammatory infiltrates, but characterizing the cells, what genes they are expressing, and how they interact with each other is challenging. Chiara’s work in analyzing this large data set has been instrumental in increasing our understanding.
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Stem cell scientists: Join the next Southern California Stem Cell Seminar on June 13, 2024 at 9:30 a.m. PDT featuring Giorgia Quadrato, Ph.D., of the University of Southern California. This event is in collaboration with UC San Diego and hosted by Evan Snyder, M.D., Ph.D. Register: https://bit.ly/4bIN4Hz #stemcells
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More than 120 pancreatic cancer researchers from the West Coast traveled to San Diego from as far as Vancouver to attend the 2024 PancWest Symposium held at Sanford Burnham Prebys on May 17. The PancWest Symposium is held every two years in a different city to showcase expert scientists who are making important contributions to the field of pancreatic cancer research, including tumorigenesis, tumor progression and the discovery of novel therapeutic paradigms, such as immunomodulation and metabolic targeting. "Being a part of PancWest has been a transformative experience,” shares co-host Pamela Itkin-Ansari, Ph.D., adjunct professor in the Institute’s Development, Aging and Regeneration Program. “The exchange of groundbreaking research and innovative ideas among leading experts advanced our scientific understanding.” “It also paved the way for new therapeutic strategies, ultimately offering hope and improved outcomes for patients battling pancreatic cancer," adds co-host Cosimo Commisso, Ph.D., director of, and associate professor in, the Institute’s Cancer Metabolism and Microenvironment Program. Read more: https://bit.ly/4dO0CD5 #pancreaticcancer #cancerresearch #tumorigenesis #tumorprogression #immunomodulation #metabolictargeting
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Board Certified Regulatory Toxicologist Assuring Safety for Food, Feed, and Nutrition Products
1moCongratulations to you and your team Brooke M. Emerling ! Nice work.