Our recent manuscript published in 𝐧𝐩𝐣 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐎𝐧𝐜𝐨𝐥𝐨𝐠𝐲 details the development of our pan-tissue, AI-powered #digitalpathology pipeline for segmentation, identification, and classification of nuclear features directly from H&E whole-slide images. https://lnkd.in/eJwF_YZH A team of PathAI scientists led by John Abel utilized #deeplearning and trained PathExplore™ to dive deep into tumor biology, characterizing cell nuclei to help pathologists identify novel biomarkers, examine the relationship between nuclear morphology and genetic factors, and advance research into oncogenic transformation. Read more about the nuclear morphology and how researchers can utilize the PathExplore™ platform to expedite insights into #cancer biology, detection, and progression. #biotech #biotechnology #AI #pathology #oncology #deeplearning #machinelearning #cancerresearch PathExplore™ is for research use only. Not for use in diagnostic procedures.
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#checkout the #Poster from our ATOM-Frederick National Laboratory for Cancer Research cohort of #students from The Data Science Institute at Columbia University lead by ATOM #mentor, Pinyi Lu! #Generative #Molecular #Design for #Novel #Cancer #Drugs #Drugdiscovery faces the challenge of efficiently selecting viable candidates from an immense chemical space estimated between 10.. and 10⁸⁰ molecules. Recent advancements in AI have introduced transformative tools such as #AI -based prediction and #generativedesign, significantly enhancing the discovery #pipeline. This #project utilizes the FNL-GMD pipeline (https://lnkd.in/gGyEbWYs) developed by Frederick National Laboratory for Cancer Research to optimize molecular properties (e.g., solubility). This approach accelerates the design of potential #drugcandidates, optimizing multiple parameters in silico, thus reducing the need for extensive synthesis and testing. #ML #AI #partnership #nextgeneration #drugdiscovery
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This past week, we published our article, 𝐀𝐈 𝐩𝐨𝐰𝐞𝐫𝐞𝐝 𝐪𝐮𝐚𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐧𝐮𝐜𝐥𝐞𝐚𝐫 𝐦𝐨𝐫𝐩𝐡𝐨𝐥𝐨𝐠𝐲 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫𝐬 𝐞𝐧𝐚𝐛𝐥𝐞𝐬 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐠𝐞𝐧𝐨𝐦𝐞 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐩𝐫𝐨𝐠𝐧𝐨𝐬𝐢𝐬, in npj Precision Oncology where we describe the development of of a pan-tissue, #deeplearning based digital pathology pipeline for nucleus detection, segmentation, and classification enhancing nuclear morphologic #biomarker discovery. https://lnkd.in/eJwF_YZH Did you know that quantification of nuclear morphology is available as part of the PathExplore™ suite of algorithms? Here it is in action! Dive deep into nuclear morphology, cell & tissue segmentation, and more with PathExplore™ for #cancerresearch. Access our demo slides on our AISight® TxR platform so you can see all of the capabilities of AI-powered pathology has to offer: https://lnkd.in/eCn4xwj2 PathExplore™ is for research use only. Not for use in diagnostic procedures. #pathology #biotech #AI #biotechnology #oncology
Dive deep into nuclear morphology with PathExplore™
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Day 3 of #30daysofbiotechinnovation What if I tell you that cells talk? How would you react? Well, here is some exciting news for you! Scientists believed DNA was the control centre of cells. However, a new study from H. Lee Moffitt Cancer Center & Research Institute proposed a new information processing system that works alongside DNA. This new system uses electrical charges across cell membranes, called ion gradients, to send messages throughout the cell. Proteins from the cell's skeleton become information highways, allowing ion signals to travel deep inside the cell. This system allows for quick, targeted responses to specific signals and might be able to make decisions without relying solely on pre-programmed DNA instructions. #sciencedaily #biotechnlogy #technology #fascinating #research https://lnkd.in/ginaUSdi
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Discovery of the new planet… The Nano-Iceland! Actually, this is a little crystal ice found in my grid during the acquisition on the #Aquilos2 (Thermo Fisher Scientific). Behind the ice we can see a HEC1A cells used to understand the autophagic processes in #cancer #stemcell. Here, we seek to describe molecular events involved in #membrane bending and #autophagosome formation using #Cryo-EM pipeline. Image capture by Stephane TACHON and Kennedy Bonjour, PhD Bonjour at @Nanoimaging Core Facility and Thomas Wollert lab/Institut Pasteur #science #health #research #future #microscopy #education #images #bioimaging #InstitutPasteur #autophagy #drugdiscovery #cryo-FIB
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Take a look into the PathExplore™ platform and access the demo!
This past week, we published our article, 𝐀𝐈 𝐩𝐨𝐰𝐞𝐫𝐞𝐝 𝐪𝐮𝐚𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐧𝐮𝐜𝐥𝐞𝐚𝐫 𝐦𝐨𝐫𝐩𝐡𝐨𝐥𝐨𝐠𝐲 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫𝐬 𝐞𝐧𝐚𝐛𝐥𝐞𝐬 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐠𝐞𝐧𝐨𝐦𝐞 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐩𝐫𝐨𝐠𝐧𝐨𝐬𝐢𝐬, in npj Precision Oncology where we describe the development of of a pan-tissue, #deeplearning based digital pathology pipeline for nucleus detection, segmentation, and classification enhancing nuclear morphologic #biomarker discovery. https://lnkd.in/eJwF_YZH Did you know that quantification of nuclear morphology is available as part of the PathExplore™ suite of algorithms? Here it is in action! Dive deep into nuclear morphology, cell & tissue segmentation, and more with PathExplore™ for #cancerresearch. Access our demo slides on our AISight® TxR platform so you can see all of the capabilities of AI-powered pathology has to offer: https://lnkd.in/eCn4xwj2 PathExplore™ is for research use only. Not for use in diagnostic procedures. #pathology #biotech #AI #biotechnology #oncology
Dive deep into nuclear morphology with PathExplore™
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The Czech language not only adopts words from other languages but also comes up with some of them, now used worldwide. It's not just Čapek's ROBOT 🤖 or the DOLLAR💰, the original Czech tolar. One of the relatively new Czech terms is also MIGRASTATICS. Where did they come from? Migrastatics were introduced a few years ago by the team of cell biologist Jan Brábek from the Faculty of Science, Charles University for substances that prevent invasiveness and metastasis of cancer cells. The team uses the Telight Q-Phase 🔬 for unique observation of tumor cell invasiveness mechanisms in collagen gel environments, which other methods can't detect. Migrastatics may represent a future breakthrough in the treatment of solid tumors. #migrastatics #qphase #science #cancertreatment
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New algorithm alert. A team of researchers at Insilico Medicine just published on the feasibility of using a new algorithm called Quantum-assisted Fragment-based Automated Structure Generator (QFASG) in automated drug design. ◾ QFASG utilizes advanced chemoinformatic techniques to construct novel small-molecule structures from a library of molecular fragments. ◾ The algorithm employs a two-part approach: first, probes are strategically placed within target binding sites, and then structural growth occurs through iterative modules, resulting in the generation of diverse compound libraries. ◾ To demonstrate its effectiveness, the researchers successfully applied QFASG to generate new small-molecule inhibitors of two pharmacological targets involved in cancer pathogenesis -- ATM and CAMKK2 kinases. The findings were published in Frontiers in Chemistry. *Link to release in comments #ai #genai #algorithm #chemistry #medchem #cancer #quantum Alex Zhavoronkov Sergei Evteev Ivan Semenov Alex Aliper
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Inside your cerebral cortex is a complex network of excitatory and inhibitory neurons. Therefore, to generate more effective therapeutics for treating neurological disease, scientists need access to in vitro cell models that help mimic the fine balance of excitatory and inhibitory signals that define brain function. Our latest data, generated in partnership with Charles River Laboratories shows our inhibitory ioGABAergic Neurons™ reliably modulate the network activity of tri-cultures with excitatory ioGlutamatergic Neurons™ and astrocytes. Using these cells, scientists can develop functional assays that more accurately represent the complexity of the human brain. Explore this new data: https://hubs.ly/Q02lMzYk0 #research #DrugDiscovery #optiox #ioCells #GABA #epilepsy #schizophrenia #autism #AlzheimersDisease #iPSCs #data #launch
ioGABAergic Neurons | ioCells | bit.bio
bit.bio
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◾ Learning Opportunity: John D. Carpten, PhD, Chief Scientific Officer at City of Hope will present 'Population Genome Science and Precision Oncology' on the next virtual IPM Speaker Series. ◾ December 13, 2023 at 4:00pm ET ◾ Join on Zoom: [https://lnkd.in/eX8EzNGK] with Passcode [#086072]. About the Expert: ◾ Research Disciplines ➡ genome science, tumor profiling, cancer cell biology, functional #genomics, health disparities, and #precisionmedicine. ◾ Research Program Goals ➡ to discover #molecular alterations in #cancer and to translate these findings into new approaches for prevention, diagnosis, and treatment. ◾ Developments in progress ➡ cutting-edge technologies and novel bioinformatics approaches for discovery research.
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📍 Evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma Liu et al. reported integrative molecular and spatial characterization of 147 acral melanomas (AM) using genomics, bulk and single-cell transcriptomics, and spatial transcriptomics and proteomics. Highlights 🔸Invasion-preferred drivers and adnexal involvement predict early invasion of AM in situ 🔸Subclonal diversification accelerates the regional expansion of invasive AM 🔸APOE+/CD163+ macrophages promote tumor epithelial-mesenchymal transition via IGF1-IGF1R interaction 🔸APOE and CD163 staining is a prognostic biomarker for AM. ➡ More details: https://lnkd.in/exsaqvEX #PekingUniversity #spatialomics #spatialbiology #singlecellanalysis #singlecell
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Deep Learning | Reinforcement Learning
3wRichard Gault