🔬 Why Small-Molecule Drug Discovery Deserves Our Focus 🔬
I came across this article that my colleagues shared with the team, and I found it to be quite interesting. In the world of drug discovery, the spotlight is shifting back to small molecules, and here's why it matters!
💥 Resurgence of Small Molecules: Over the past decade, small molecules have proven their worth in drug development, challenging the notion that biologics were the future. New classes of molecules, such as PROTACs and molecular glues, are making waves, with tools like machine learning and AI fueling this revival.
📊 Small Molecules: A Dominant Force: Globally, approximately 90% of all drugs sold are small molecules. Since they have been a foundation of the pharmaceutical business for more than a century, technological developments and advances in synthesis methods have created new opportunities for cutting-edge small-molecule medications.
🎯 Hitting the Right Targets: Finding a key to fit within a protein is no longer the only option available to small molecules. Drug development is being revolutionised by induced-proximity molecules and covalent inhibitors. They have the ability to attach themselves to reactive amino acids on proteins and even unite proteins to perform a joint function. Once thought to be undruggable, RNA is becoming a desirable target. Researchers are finding small molecules that interact with the 3D structures of RNA.
🌟 A New Age for Medicinal Chemists: We're not just in a golden age; it's a renaissance. What's "druggable" is being redefined by new technologies and innovative methods. Small molecules have evolved beyond recognition.
🔗 CCDC's Role: The Cambridge Crystallographic Data Centre (CCDC) stands at the intersection of this small-molecule revolution. Our tools are vital in understanding molecular interactions and designing effective drugs.
Let's connect and explore how CCDC can enrich your work. I would like to invite you to schedule a meeting to discuss the valuable offerings that CCDC brings to the table and how we can collectively elevate your drug discovery work. Your insights, ideas, and perspectives are crucial. Let's shape the future of drug discovery together! 🚀
#Pharmaceuticals #DrugDiscovery #SmallMolecules #Innovation #AIinPharma #CCDC
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Let's keep the conversation going! 💬
Great Opportunity!