NCI Center for Cancer Research’s Post

📣 REGISTER NOW: Join us at our Scientific Symposium Celebrating Steven A. Rosenberg's 50 Years at National Cancer Institute (NCI) - September 26-27, 2024! Virtual attendance is also available via the registration link in the event description. 👇

📣 GIST AWARENESS DAY: The NIH Succinate Dehydrogenase (SDH)-Deficient and Ultra Rare GIST Clinic, started in 2008, is the oldest rare tumor specialty clinic held at the NIH Clinical Center (CC). SDH-deficient GIST, or gastrointestinal stromal tumor, is a rare cancer that starts in the digestive tract. Each year, CCR staff in our Pediatric-Oncology Branch host a clinic in collaboration with the My Pediatric and Adult Rare Tumor network to bring experts and patients together. Data collected in the clinic is giving scientists new ideas for how to treat these tumors. ➡ Learn more about Rare Tumor Clinics at National Cancer Institute (NCI): https://lnkd.in/ed2mjGfX

💡 NEW FINDINGS: CCR researchers used a multi-omics approach to discover vulnerabilities of IRF4, a driver of multiple myeloma. They discovered several potential new targets to treat the disease. ➡ Read more: https://lnkd.in/eZJz6XBu These findings were led by Ryan M. Young, Ph.D., and Jagan R. Muppidi, M.D., Ph.D., both Stadtman Investigators in CCR's Lymphoid Malignancies Branch. Insights from their research are helping to identify novel therapeutic targets, to exploit druggable pathways in lymphoid malignancies and to understand the intersection of the immune response and generation of malignancies derived from B cells. National Cancer Institute (NCI), National Institutes of Health (NIH): Intramural Research Program (IRP), The National Institutes of Health #CancerResearch #MultipleMyeloma #Innovation #Health #CancerGenomics

Several of our investigators are featured in this piece. Check it out below! 👇 National Cancer Institute (NCI), National Institutes of Health (NIH): Intramural Research Program (IRP), Sadhana Jackson, Freddy E Escorcia, MD, PhD (freddyeescorcia), Andrea Apolo

💡 NEW FINDINGS: CCR researchers developed an animal model to study fusion-negative rhabdomyosarcoma, a childhood cancer. The model provides detailed insights into tumor invasion and metastasis, which could help guide new therapeutic avenues for the disease. These findings were spearheaded by a team led by Paul A. Randazzo, M.D., Ph.D., Senior Investigator in the Laboratory of Cellular and Molecular Biology. ➡ Read more: https://lnkd.in/ea2J9sAy National Cancer Institute (NCI), National Institutes of Health (NIH): Intramural Research Program (IRP) #CancerResearch #ChildhoodCancer #Innovation #Health #Medicine

📣 TRAINEE PERSPECTIVES: Here at the National Cancer Institute (NCI) and within CCR, our innovative training programs educate and mentor the next generation of physician-scientists, from summer students to faculty members. We are committed to training and supporting the next generation of diverse cancer researchers. Train at NCI, National Institutes of Health (NIH): Intramural Research Program (IRP) ➡ Stephen Andrews, a former postbaccalaureate fellow in the laboratory of Samira M. Sadowski, M.D., Surgical Oncology Program, wrote about his experience and how it prepared him for medical school in the NIH Catalyst: https://lnkd.in/dEUnSEUZ ➡ Several other trainees who worked with CCR through the Medical Research Scholars Program or as a Cancer Research Training Award fellow in our Urologic Oncology Branch additionally offered their perspectives: https://lnkd.in/d5nJwrAc #CancerResearch #Training #Health #Innovation #Every1HasARole

Congratulations to Ruth Nussinov, Ph.D., Senior Investigator in our Cancer Innovation Laboratory, for receiving this honor! 👏 National Cancer Institute (NCI), EMBO

💡 ONGOING RESEARCH: DNA replication can generate potentially catastrophic double-strand DNA breaks. A new study from CCR scientists, led by Andre Nussenzweig, Ph.D., Chief of the Laboratory of Genome Integrity, details how these breaks arise and how cells repair the damage. Understanding the repair of replication-associated double-strand breaks is important for devising better cancer therapies, as many systemic chemotherapies kill cancer cells by triggering these kinds of breaks. National Cancer Institute (NCI), National Institutes of Health (NIH): Intramural Research Program (IRP), andre nussenzweig �� Read more: https://lnkd.in/e4xhgeWa #CancerResearch #DNA #CancerGenome #Innovation #Technology