Co-Founder & Chief Medical Officer at Accomplish Health | Healthcare Futurist | Clinical Assistant Professor of Medicine - OUHSC
🔸NTS-GLP1R neurons mediate satiety-related weight loss. 🔸AP-GLP1R neurons mediate food aversion and nausea. TLDR: GLP1-mediated weight loss and nausea have distinct neural circuits. It’s possible to create a GLP1RA with biased/selective agonism toward NTS-GLP1R, which could limit GLP1-related side effects (SEs). https://t.co/sPGrK7MZVs