The Potential of Covalently Immobilized Heparin Blood Purification as a Supportive Therapy for an Underperforming Liver.
The function of resident Kupffer macrophages in the liver is vitally important for clearing and catabolizing unwanted circulating tumor cells (CTCs) and potentially proinflammatory, prothrombotic late apoptotic, and early necrotic neutrophils from the blood. Furthermore, Kupffer macrophages also greatly facilitate the clearance of unwanted pathogens from the blood circulation, helping to minimize the devastating consequences of circulating tumor metastasis and septic shock-driven DIC circulatory collapse, that frequently ends in catastrophic circulatory failure. This vital hepatic phagocytic clearance is depressed and increasingly less self-sufficient during severe disease progression, triggered by cancer, septicemia, and many other infectious and non-infectious disease triggers. It has been estimated that greater than 80% of the body's innate macrophage-mediated phagocytic clearance capacity for deleterious circulating unwanted cells is likely accomplished by the liver in a normal healthy person.
Importantly, it has also been demonstrated that CTCs, unwanted pathogens, and dying neutrophils have increased capacity to selectively bind heparan sulfate/heparin. Making covalently immobilized heparin whole blood purification an excellent and safe potential hepatic supportive therapy when this innate phagocytic clearance capacity is overwhelmed and consistently underperforming. For more on the potential of this, likely, hepatic supportive therapy. Please visit ExThera Medical's website. https://lnkd.in/gg4dzRB6
As a final note. A likely explanation for how this blood purification therapy works to help remove diverse and deleterious unwanted cells from the blood of a suffering patient is to recognize that hyperactivated and dying cells, predominantly neutrophils, release their chromatin extracellularly to sequester CTCs and pathogens. These large molecular-weight extracellular chromatin structures are known as Neutrophil Extracellular Traps (NETs). NETs are populated with dual DNA-heparin-binding proteins providing avid affinity for covalently immobilized heparin.
In summary, these NETs and other extracellular nucleosomal chromatin released by other dying cells, likely help facilitate the removal of deleterious CTCs, pathogens, and NETotic neutrophils from the circulation when the Mononuclear Phagocytic System (MPS) is increasingly failing to do so. Persistently elevated circulating NET formation positively correlates with the severity of many infectious and non-infectious disease triggers. To learn more about this, one can review the many peer-reviewed NETosis research articles I have previously posted and that others have provided for our benefit to learn from one another. Thanks! to all who share their important research findings and interpretations of this research.
Consultant Physician Genitourinary Medicine(Sexual Health and HIV) MRH Portlaoise , and Mullingar Medical Director of letsgetchecked since 2014
1wWell done 👏🏻 to the whole team and of course Rogers A . Muldrow