Jonathan Schwartz’s Post

https://lnkd.in/gw9vX6ne This is very encouraging! The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth. As reported in 2023, blocking USAG-1's interaction with other proteins encourages bone morphogenetic protein (BMP) signaling, which triggers new bone to generate.

TL:DR; Regenerative medicine update - tooth regrowth trial to start in Japan this summer in a world first 🔥 Across the animal classes, many animals continues to grow teeth throughout life. Most famous are probably sharks (Chondrichthyes), but for something more familiar, just think of the wild pig/boar (Mammalia) which will continue to grow tusks throughout life. Humans do not continue growing teeth, but interestingly, the lack of growth comes from active suppression rather than lack of activation. In this interesting update from Japan, the scientists have found a way to block the active supression in humans, at which point tooth growth starts again. Japan has been at the forefront of dental regeneration for decades, so it's richly deserved to see this milestone go to Japan. It will be super interesting to see if this pans out, and I am rooting for the team at Kitano Hospital in Osaka! 🚀

🌟 Exciting Breakthrough in Dental Medicine! 🌟 Kyoto University Hospital is set to begin the world’s first human trial of a revolutionary tooth-regrowing drug this September. This innovative treatment targets the USAG-1 protein, which suppresses tooth growth, allowing new teeth to develop. 🔬 The trial will involve 30 men aged 30-64 who are missing molars. If successful, the treatment could be available by 2030, offering hope to millions with missing teeth. 🦷 Previous animal trials have shown promising results, growing new teeth in mice and ferrets. The research team, led by Dr. Katsu Takahashi, is also planning to extend trials to children with congenital tooth deficiency. This could be a game-changer for dental health! Stay tuned for updates on this groundbreaking research. I would like to acknowledge chatGPT for helping me write the summary. #DentalInnovation #MedicalResearch #ToothRegeneration #HealthcareAdvances #KyotoUniversity #Biotechnology

World-first tooth-regrowing drug will be given to humans in September The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030. The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects. https://lnkd.in/gafmARzm

An intravenous treatment that can regenerate teeth? That would be a game-changer! I shared the news about the successful animal trials many months ago and now it seems the Kyoto University Hospital will launch a clinical trial with human patients in 2025. They will include 30 male patients aged 30-64 who are missing at least one molar. "𝐹𝑜𝑙𝑙𝑜𝑤𝑖𝑛𝑔 𝑡ℎ𝑖𝑠 𝟣𝟣-𝑚𝑜𝑛𝑡ℎ 𝑓𝑖𝑟𝑠𝑡 𝑠𝑡𝑎𝑔𝑒, 𝑡ℎ𝑒 𝑟𝑒𝑠𝑒𝑎𝑟𝑐ℎ𝑒𝑟𝑠 𝑤𝑖𝑙𝑙 𝑡ℎ𝑒𝑛 𝑡𝑟𝑖𝑎𝑙 𝑡ℎ𝑒 𝑑𝑟𝑢𝑔 𝑜𝑛 𝑝𝑎𝑡𝑖𝑒𝑛𝑡𝑠 𝑎𝑔𝑒𝑑 𝟤-𝟩 𝑤ℎ𝑜 𝑎𝑟𝑒 𝑚𝑖𝑠𝑠𝑖𝑛𝑔 𝑎𝑡 𝑙𝑒𝑎𝑠𝑡 𝑓𝑜𝑢𝑟 𝑡𝑒𝑒𝑡ℎ 𝑑𝑢𝑒 𝑡𝑜 𝑐𝑜𝑛𝑔𝑒𝑛𝑖𝑡𝑎𝑙 𝑡𝑜𝑜𝑡ℎ 𝑑𝑒𝑓𝑖𝑐𝑖𝑒𝑛𝑐𝑦, 𝑤ℎ𝑖𝑐ℎ 𝑖𝑠 𝑒𝑠𝑡𝑖𝑚𝑎𝑡𝑒𝑑 𝑡𝑜 𝑎𝑓𝑓𝑒𝑐𝑡 𝟣% 𝑜𝑓 𝑝𝑒𝑜𝑝𝑙𝑒. 𝑇ℎ𝑒 𝑡𝑒𝑎𝑚 𝑖𝑠 𝑟𝑒𝑐𝑟𝑢𝑖𝑡𝑖𝑛𝑔 𝑓𝑜𝑟 𝑡ℎ𝑖𝑠 𝑃ℎ𝑎𝑠𝑒 𝐼𝐼𝑎 𝑡𝑟𝑖𝑎𝑙 𝑛𝑜𝑤." If the trial is successful, the therapy could be available to patients with any permanently missing teeth within six years.

Human equivalent of shark teeth? 😂 🦈 A quick overview: The world's first human trial of a tooth-regrowing drug will commence in September 2024 at Kyoto University Hospital. This trial will involve 30 men aged 30-64 missing at least one molar. The drug (successful in animal models) blocks the USAG-1 protein, allowing new teeth to grow. Following this, a trial for children aged 2-7 with congenital tooth deficiency will begin. If successful, the treatment could be available by 2030, offering a permanent solution to tooth loss.

Welcome to the Veranex Image of the Month! Today, you be the Pathologist! Where was this bone seen? Share your response in the comments section below and let's discuss!   #medicaldevices #innovation #pathology #preclinicalresearch Click below for the answer! https://lnkd.in/g3WMPNkX

This article reports on the application of a modified autologous cultured epithelial grafting technique developed for treating refractory vitiligo, with clinical outcomes that are encouraging for future therapies. https://lnkd.in/dRFTfgq6

Check out our paper on ongoing fibroblast activation in patients after acute myocardial infarction using FAPI-PET/MRI #fapi #PET #fibroblastactivation #myocardialinfaction #imaging

A phase 2 study found that EYP-1901 with supplemental aflibercept as needed was non-inferior to aflibercept alone, pointing to a potential new treatment option that could reduce the frequency of dosing for patients with neovascular age-related macular degeneration (nAMD). Read the full article here ⤵️ #AMD #AgeRelatedMacularDegeneration #MacularDegeneration