Johnson & Johnson Innovative Medicine’s Post

My colleagues at Johnson & Johnson Innovative Medicine are at the 2024 European Academy of Neurology Meeting, presenting our latest Phase 3 data from a clinical study of an investigational therapy for patients living with generalized myasthenia gravis (gMG). I am proud to work at #MyCompany, as we are researching potential treatment options to address the significant unmet needs remaining for people with gMG, as many patients still need sustained disease control. I am looking forward to discussing the future of gMG and other neuroscience autoantibody-driven diseases with other experts at #EAN2024.    #JNJNeuroscience #JNJImmunology 

🌟 We are delighted to share that groundbreaking collections have been launched during the 9th Mediterranean Neuroscience Society (MNS) Conference (Tunisia), which was proudly sponsored by Frontiers! The MNS2023 meeting brought together brilliant minds and passionate researchers in the field of neuroscience, fostering a vibrant environment for intellectual exchange and innovative ideas. 🚀 👉 Take a look at our first collection 📝: "Therapeutics and Clinical Management of Neurological Disorders: Exploring Novel Approaches and Biomarkers of Vulnerability" 🧠💡, led by the renowned researchers Dr. Jacques Noel and Dr. @Amira Zaky. Stay updated on its progress by visiting our dedicated website: https://lnkd.in/dnsC7hsp or, if you are interested in contributing, make sure to connect with us by registering to: https://lnkd.in/dkehk79M Manuscript Submission Deadline: 15 April 2024 #NeurologicalDisorders #PrecisionMedicine #Biomarkers #TherapeuticApproaches #Innovation #Research #ClinicalManagement

The collaboration between pericytes and neurons extends to the maintenance of the blood-brain barrier (BBB), a protective barrier that controls the passage of substances between the bloodstream and the brain. Pericytes actively participate in BBB regulation, influencing the entry of molecules crucial for synaptic plasticity, a fundamental process in long-term memory

August is #SpinalMuscularAtrophyAwarenessMonth and at the #AHN Neuroscience Institute, we provide a precise diagnosis to help patients manage symptoms & live their best life with the disease. Learn more https://bit.ly/3vfBujJ #SMA #spinalmuscularatrophy #ahnneuroscience

📽 From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders — a video abstract by Dr. Masaru Tanaka and Dr. László Vécsei. 👨🔬 This video abstract is a part of the Editorial for the Special Issue "Genetic, Epigenetic, Environmental, and Pharmacological Models for Neuroscience, Neurologic Diseases, and Psychiatric Disorders: Advancement in Bench-to-Bedside Translational Research". 🔗 https://lnkd.in/dWnn3a_N 📖 Read the full text ➡️ https://lnkd.in/dAJv6EZm MDPI

Watch the Webinar on demand: 🔎 Discover the Power of Mini-Brains 🔎 👉 Sign up here: https://ow.ly/ZqlH50PCN03 In this webinar we are peering into the building blocks of the mind using antibodies as a tool to spatially visualize different neuronal lineage markers in human cortical organoids. Veronica Pravata, Postdoctoral Research Fellow at LMU delves into the fascinating world of brain organoids and explores their potential to shed light on the building blocks of the mind. You will learn: ✅ How brain organoids are providing unprecedented insights into brain development. ✅ How this knowledge is helping our understanding of a range of neurological and psychiatric disorders. 👉 Sign up here: https://ow.ly/ZqlH50PCN03 #atlasantibodies #neuroscience #brainresearch #neurallineage #stemcells #scicomm

Happy to share our newest review on the bi-directionality of the microbiome-gut-brain-axis, in Frontiers in Neuroscience. 🧠🦠 If you’d like to know more about the topic, check it out here: https://lnkd.in/dA2nGxcV #microbiome #gutbrainaxis

New research published! 📚 In his recent paper in Nature Neuroscience, ARMGO's founder, Andrew R. Marks, MD, and his team at Columbia University, NY demonstrated the role of Ryanodine Receptor 2 (RyR2) in the development of #heartfailure-induced #cognitive dysfunction. In the process they confirmed that heart failure is a systemic disease involving the brain as well. Cognitive dysfunction is seen in as many as 90% of heart failure patients, who experience a range of symptoms including forgetfulness and difficulty learning. As well as impacting quality of life, cognitive dysfunction has a significant impact on an individual's ability to self-care, follow treatment regimens and notice changes in symptoms. The team's #research concluded that RyR2, an intracellular calcium release channel within hippocampal neurons, is subject to post-translational modifications (PTM) in individuals with heart failure. PTMs occured as a result of increased adrenergic signalling and activation of the transforming growth factor-beta pathway. As a consequence neuronal RyR2 became leaky along with modified cardiac RyR2. In a mouse model of heart failure the neuronal calcium leak induced protein expression changes that lead to cognitive dysfunction. Treatment with a brain penetrant Rycal® drug was able to restore normal calcium handling in mouse neurons and to eliviate cardiogenic dementia effects in mice. The landmark paper sheds a new light on heart failure-induced cognitive dysfunction and the causal role of RyR2-related intracellular calcium signalling in the brain. These findings expand the role of RyR2 in heart failure beyond its established cardiac effects. Want to find out more? Read the full paper here: https://rb.gy/8qb5c

wonderfull advancements in Quantum Biology will lay foundation for more and more modern medical advancements and epigenetics, here is the evidance for that... #epigenetics #biology #medicaladvancements #Quantum #Quantumbiology

Knowledge is power.