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New way to generate human cartilage University of Montana researchers and their partners have found a new method to generate human cartilage of the head and neck.

Chet Mortiz, a C.J. and Elizabeth Hwang Endowed Professor in UW ECE, with joint appointments in rehabilitation medicine, physiology, and biophysics, is the lead author of a new study on non-invasive spinal cord electrical stimulation, which he is using in the Amplifying Movement & Performance (AMP) Lab to help restore hand and arm function for paralyzed individuals. The pictured study participant, Jon Schlueter, suffered a spinal cord injury in 2005 that severely limited the use of his arms and hands. By taking part in the study, Schlueter has been able to play guitar again. This groundbreaking work shows that 72% of study participants, like Schlueter, improved their hand strength and function. This research gives paralyzed individuals new hope for substantial functional improvements, and advances the fields of neurotechnology and rehabilitation. Learn more about how this work is changing lives in the link below. #uwece Chet Mortiz: https://lnkd.in/gWRsqCGg UW Physiology and Biophysics https://lnkd.in/gH67XBNS

Is there a risk to #babies in the womb through #nanoparticles? Tina Buerki-Thurnherr and her team from Empa's Particles-Biology Interactions laboratory in St. Gallen are investigating how this protective mechanism copes with nanoparticles. Together with clinical partners from the Kantonsspital St.Gallen KSSG and research partners from the Université de Genève, the Amsterdam UMC and the Leibniz Institute for Environmental Medical Research in Düsseldorf, the team is investigating the consequences of common nanoparticles such as titanium dioxide or diesel soot on the function of the placenta and their indirect damage to embryonic development. 👉️Experiments showed that nanoparticles in placental tissue disrupt the production of a large number of messenger substances. And it is these messengers that can trigger serious changes in embryonic development, such as disturbed blood vessel formation. 👏The paper "Nanoparticles Dysregulate the Human Placental Secretome with Consequences on Angiogenesis and Vascularization" has been selected as an outstanding article by Advanced Science. 🔗https://lnkd.in/euHCVhtd The project «Exploring indirect embryo-fetal risks of nanomaterials: Interference with inflammatory, vascular and endocrine signaling from human placental tissue» is supported by the Swiss National Science Foundation SNSF. Related work: 🔗 Empa's Zukunftsfonds – Funding ambitious research: A chip to replace animal testing: https://lnkd.in/g29_uYc4 🔗Hormone-producing fungi: Babies burdened by environmental estrogens in mothers' wombs: https://lnkd.in/eTA8p3DG 🔗New 3D model of the human placental barrier: Medication for the unborn baby: https://lnkd.in/eH73-8SK Author: Andrea Six

New way to generate human cartilage https://lnkd.in/ghdHDbN9 University of Montana researchers and their partners have found a new method to generate human cartilage of the head and neck.

🔊 The 4th event in our collaborative review pilot with Elsevier for Life Sciences Current Research in Neurobiology journal (#CRNEUR) has been rescheduled for Thurs Oct 19th at 14:00 UTC, we will be reviewing this preprint together: https://lnkd.in/eKShuzVK 🗓 Date: Oct 19 2023 🕑 Time: 2pm UTC 🖊 Registration: https://lnkd.in/ep2hnGrM You may participate in any way you like, whether to observe the process and learn more, join as a discussion participant and help contribute to the notes, or help co-author the final review (with optional recognition) which will be published on prereview.org with a DOI. You can read more about the pilot & see outputs from the previous events in the series here: https://lnkd.in/ewpZWxjg Please do share with anyone who may be interested in joining. #AuditoryNeuroscience #openpeerreview #preprintpeerreview

📢 Exciting News: Our Latest Preprint has been Published! 📢 I'm thrilled to announce the publication of our recent preprint titled "Early Deprivation Impairs Perforant Pathway Connectivity and Contextual Memory in Adolescent Male Mice"! 🧠🔗 In this study, we explored the intriguing relationship between early-life adversity and hippocampal connectivity using a mouse model. Our findings reveal fascinating insights into the impact of gender-specific factors on memory function and brain development. 🐭🔬 Key Highlights: ✅ Early-life adversity led to reduced reelin-positive projections from the lateral entorhinal cortex to the dorsal hippocampus. ✅ Impaired contextual memory and disrupted structural connectivity were observed, particularly in males. ✅ This study opens new avenues for understanding how early experiences shape brain circuits and influence memory processes. I'm grateful for the dedicated team that contributed to this research, and I invite you to delve into the details by accessing the preprint here: https://lnkd.in/gYKPQfQw Let's keep the conversation going! I'd love to hear your thoughts and insights on our findings. Your perspectives could contribute to further advancements in this exciting field. 🌟🧪 #NeuroscienceResearch #BrainDevelopment #EarlyLifeAdversity #HippocampalConnectivity #PreprintPublication #ResearchMatters

Congratulations to Elsevier Senior Acquisitions Editor Elizabeth Brown and book editors Farshid Sefat (University of Bradford) and Morvarid Saeinasab, Ph.D. (The University of Manchester) for the publication of "Regenerative Medicine in the Genitourinary System." This comprehensive guide offers an overview of the cutting-edge field of tissue engineering used to treat genitourinary disorders and infertility. Key Features: 🔹 Provides in-depth principles of tissue engineering in urinary and reproductive systems 🔹 Showcases exemplary cases of tissue engineering and regenerative medicine in tackling diseases and disorders related to the urinogenital system 🔹 Includes insightful chapters on erectile dysfunction as well as tissue engineering strategies to treat male and female infertility #RegenerativeMedicine #TissueEngineering #GenitourinarySystem #BookRelease #Research #Innovation #Regeneration #Biomaterials #MedicalScience

Our understanding of brain function spans multiple scales from the molecular with ions and neurotransmitters to the mesocopic with microscircuits mediated by specific interneuron to the systems level with functional connectivity between brain regions. Great advances and discoveries have been made at each level; however, there has been little integration between levels for practical reasons and the brain has remained a black box. Through the development of next generation tools to probe the nervous system, we are finally able to gain insights that span multiple scales. It’s multi-scale efforts like this, where cellular based analyses are done over the entire brain, that will be the keys to unlocking the mystery that is brain and the mind - the last great frontier.

Postdoctoral scholar Keundong Lee is one of the first authors on a recent Nature Communications paper describing a new way to manufacture deep brain electrodes. He shares how he got involved with the project, his work over the past years in the UC San Diego research group of Professor Shadi Dayeh, and his hopes for the device, in this video. These electrodes allow minimally-invasive, high-resolution recording as deep as 4 inches inside the human brain. This technology is a first step towards wireless monitoring of patients with treatment-resistant epilepsy for extended periods of time–up to 30 days–as they go about their daily lives. Beyond treatment-resistant epilepsy, the potential applications are much broader, including helping people with Parkinson’s disease, movement disorders, obsessive-compulsive disorder, obesity, treatment-resistant depression, high-impact chronic pain and other disorders. Learn more about this research here: https://lnkd.in/gxgreq9v

Microcephaly isa condition in which a baby’s head is much smaller than normal. Most children with microcephaly also have a small brain, poor motor function, poor speech, and abnormal facial features, and are intellectually disabled. Researchers believe the roots of the condition lie in the peak phase of brain development in the embryo — when the cells that eventually become neurons fail to divide normally. Clinicians can diagnose microcephaly before the baby is born using foetal ultrasound and magnetic resonance imaging. On March 19, researchers at the Affiliated Maternity and Child Health Care Hospital of Nantong University, China, the team’s findings reinforced the SASS6 gene’s role in causing microcephaly. But more importantly, the team also found that if one copy of the SASS6 gene was non-functional, the other retained at least some function. The implication was that if both copies are non-functional, the human embryo dies before it becomes a foetus. 70% or more of cases of congenital microcephaly seen in the clinic come from consanguineous marriages. These are marriages between closely related individuals, such as between uncle and niece or between first cousins.