Gareth Baynam’s Post

Prometheus Project & Natural Anamorphosis Process (Prometheus Orthogonality) In biology, homeostasis is the state of steady internal physical and chemical conditions maintained by living systems. This dynamic state of equilibrium is the condition of optimal functioning for the organism and includes many variables being kept within certain pre-set limits (homeostatic range). Variables are controlled by one or more regulators or homeostatic mechanisms, which together maintain life. Homeostasis is brought about by a natural resistance to change when already in the optimal conditions, and equilibrium is maintained by many regulatory mechanisms. All homeostatic control mechanisms have at least three interdependent components for the variable being regulated: a receptor (eg. skin mechanoreceptors), a control centre (eg. hypothalamus-locus coeruleus), and an effector (eg. immune system). (Senarelis Sinaris, A. (2020). “Natural Anamorphosis Process”. Clinical Immunology & Research, ISSN 2639-8494, Vol. 4, Issue 1.) Resistance (or equilibrium) = Homeostasis Homeostasis = Resistance (or equilibrium) When therapy by definition aims to normalize a distorted biological condition, actually what it does is to try to bring biochemical regularity (normal functioning). Now if we see it from another perspective (Anamorphosis), by intensifying or enduring the normal bio-available functioning (eurythmia), essentially, we are in a therapeutic sphere of influence via a simple reverse process thinking mechanism. If one value is equal to another value, then the second value is also equal to the first value (mathematical symmetric property of equality). N.A.P is not an ego-system, but an eco-system. (Senarelis Sinaris, A. (2020). “Natural Anamorphosis Process”. Clinical Immunology & Research, ISSN 2639-8494, Vol. 4, Issue 1.) –Alejandro Senareli-Sinari, creator of Prometheus Project

🚨 New Publication Alert! 🚨 Excited to share our latest research on the clinical profile and factors associated with mortality and poor hospital outcomes in Guillain-Barré Syndrome (GBS) patients. We used the Hughes Functional Disability Scale to define outcomes. This study adds insights to the existing body of literature and highlights data specific to Ethiopia. Check out the full paper to learn more about our research and its implications. #GBS #Neurology #ClinicalResearch #Ethiopia #Healthcare #MedicalResearch

#Active #components of #ginkgobiloba #may #improve #early #cognitive #recovery #after #stroke #Neuroscience #Cardiology -------- https://lnkd.in/gRuYH9_B -------- People with ischemic (clot-caused) stroke had better early recovery of cognitive function if treated with intravenous injections of a combination of biologically active components of ginkgo biloba during the first two weeks after the stroke, according to a preliminary study to be presented at the American Stroke Association's International Stroke Conference 2024. The meeting will be held in Phoenix, Feb. 7-9. #Ginkgobiloba is an #herb #extracted from the #dried #leaves and #seeds of the #gingkotree, one of the oldest living tree species and native to East Asia. It is widely used in traditional Chinese medicine and available as a supplement in the U.S. Compounded therapies of the active ingredients of gingko biloba, delivered by IV, are widely used to treat stroke in China because of its #potential #antioxidant #properties that may #protect #nervecells from #damage. Ginkgo biloba is not approved by the U.S. Food and Drug Administration for any medicinal use, and there is not enough evidence to support any non-FDA approved use, according to the National Center for Complementary and Integrative Health, a division of the National Institutes of Health. In early 2023, researchers from this study published the results of a multicenter trial in China indicating that people with ischemic stroke had better recovery from their overall stroke symptoms if they were treated with daily injections of ginkgo diterpene lactone meglumine (GDLM), a combination of the biologically active components of ginkgo biloba. The current investigation analyzed the cognitive recovery of participants in that study. "If our positive results are confirmed in other trials, GDLM injections may someday be used to improve cognitive function for patients after ischemic stroke," said Anxin Wang, Ph.D., an associate professor of clinical epidemiology at the Beijing Tiantan Hospital of the Capital Medical University in Beijing. The researchers analyzed the cognitive recovery of 3,163 stroke survivors (average age of 63 years; 36% women) treated for mild to moderate ischemic stroke at 100 centers in China. Starting within 48 hours of the stroke, about half of the stroke survivors were randomly selected to receive daily, intravenous injections of 25 mg of GDLM for 14 days, while the other half received daily, intravenous placebo injections. Cognitive performance was assessed before treatment, at 14 days and at 90 days using the Montreal Cognitive Assessment scale (MoCA), a 30-point face-to-face screening test of cognitive performance often used with stroke survivors. At baseline—within 48 hours of the stroke and before beginning treatment, most patients' cognitive status was moderately impaired, with an average score of 17 out of 30.

🧠 Impact of Dopamine on Mitochondrial Function and Iron Metabolism in Parkinson’s Disease #PD In our latest study, just published in Neurobiology of Disease Elsevier, we investigated the interaction between iron and dopamine metabolism and mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD). 🔬 In the study, we used neuroblastoma cells (SH-SY5Y) and dopaminergic neurons derived from induced pluripotent stem cells (iPSCs) of a control and a PD patient with an α-synuclein (SNCA) gene mutation. In SH-SY5Y cells, dopamine increased the expression of iron transporters and caused iron accumulation, suggesting that dopamine alters iron homeostasis in neuronal cells. This led to impaired mitochondrial function, evidenced by reduced respiration, mtDNA copy number, and citrate synthase activity, as well as increased oxidative stress. Similarly, in neurons from a healthy control, dopamine reduced mitochondrial fitness. However, in PD neurons with the SNCA mutation, dopamine promoted mitochondrial respiration, activated antioxidant responses, and normalized metabolite levels associated with mitochondrial function by shuttling iron between cytoplasm and mitochondria. 💡 These findings expand our knowledge on the effect of dopaminergic treatment on iron-mitochondria biochemical pathways, highlight the importance of a spatio-temporal distribution of iron and dopamine for brain function and offer new perspectives for targeted treatments to improve altered intracellular iron distribution, protect mitochondria and reduce oxidative stress in PD patients.⚕ 🤝 The study was conducted in the framework of our bilateral (Bi-Doc) doctoral programme between the Medizinische Universität Innsbruck, Austria, with Prof. Guenter Weiss, and our Institute. We extend our gratitude to the entire team, particularly PhD student Chiara Buoso, and our collaborators at Luxembourg Centre for Systems Biomedicine (LCSB) - University of Luxembourg Prof. Emma Schymanski, whose invaluable contributions have been instrumental in this journey. Chiara Buoso, Markus Seifert, Martin Lang, Corey Griffith, Begoña Talavera Andújar, Maria Paulina Castelo, Christine Fischer, Carolina Doerrier Velasco, Heribert Talasz, Zanon Alessandra, Peter P. Pramstaller, MD, Emma Schymanski, Irene Pichler & Guenter Weiss https://lnkd.in/eXS3UNAZ

Keeping the "amyloid boogeyman" alive This week's article in Nature Medicine describes Alzheimer's disease (AD) as being pathologically characterized by the deposition of amyloid-beta (Aβ) in the brain and blood vessels and by neurofibrillary tangles of tau protein. It presents evidence suggesting Aβ as a fundamental cause of AD, including cases of human transmission of Aβ pathology through medical treatments contaminated with Aβ seeds, leading to dementia with AD-like symptoms. The possibility of environmentally acquired forms of AD, similar to Creutzfeldt–Jakob disease (CJD), is raised, although it emphasizes that iatrogenic AD is likely rare and Aβ transmission in daily life is not a concern. The text also discusses the potential challenges in developing treatments due to the structural diversity of Aβ assemblies, which might lead to therapeutic resistance. However, promoting the idea that amyloid-beta is the sole cause of Alzheimer's may be misleading and potentially harmful to the broader scientific investigation into this complex disease. It overlooks other contributing factors and hypotheses, limiting the scope of research and potentially delaying the development of more effective treatments. By focusing narrowly on Aβ, the scientific community might miss opportunities to explore other pathways and mechanisms involved in AD, thereby doing a disservice to the ongoing quest to understand and effectively combat this debilitating disease fully. link: https://lnkd.in/g7NYDdRg #alzheimers #dementia #CNS #neuroscience #neurology

Pervira® is now available at Poliklinik Care Medics Pervira® by Medika Natura Sdn Bhd, with registration number MAL23036144TC, is a standardized extract of Kaempferia parviflora, containing not less than 8% 5,7-dimethoxyflavone (DMF), the highest concentration available in the market. The 5,7-dimethoxyflavone (DMF), a major flavone found in Kaempferia parviflora, has biological activities, including anti-diabetes, anti-obesity, and anti-inflammation. The latest finding 5,7-dimethoxyflavone (DMF) can be used as a natural agent to inhibit sarcopenia via improving protein turnover and mitochondria function. Sarcopenia is a muscle disease featured by the loss of muscle mass and dysfunction with advancing age. Kaempferia parviflora, commonly known as Black Ginger, has a long history of traditional use in treating various everyday ailments, including fatigue, enhancing physical fitness, and promoting longevity. Extracts from K. parviflora offer numerous beneficial effects, such as inhibiting melanogenesis, reducing skin photoaging, improving cognitive function, supporting male reproductive health, and promoting skin-whitening effects. Moreover, it contributes to the prevention of musculoskeletal aging, which includes conditions like osteoarthritis and sarcopenia At Medika Natura Sdn Bhd, we are fully committed to leading the way in pioneering innovative healthcare solutions rooted in the rich tradition of botanical medicine. We adhere to the highest standards of quality and proudly maintain compliance with healthcare and Halal regulatory standards throughout our processes. We highly recommend consulting with Dr. Kamalah Devi Murugian from Poliklinik Care Medics, located at N0. 10, Jalan BP 7/11, Bandar Bukit Puchong, 47120 Puchong, Selangor. Her clinical expertise will help tailor a plan that suits your specific health needs and goals. You can reach the clinic at 019-336 9725 to schedule an appointment. Source: 1. The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways https://lnkd.in/gAvEjDxA 2. Biofunctional properties and plant physiology of Kaempferia spp.: Status and trends https://lnkd.in/gB8PdxCv hashtag #menshealth

Migraines can often be described as a ‘curse’. An extremely painful condition, yes, but it’s more than that, having over 200 associated symptoms including brain fog, dizziness, aura, and muscular pain to name just a few.   This year in honour of Migraine Awareness Week in the UK, Lucy Saunders, key member of HRW Synapse, our team of neuroscience experts, and Internal Migraine Consultant, has shared some key insights into the development of migraine treatments and neuromodulation devices.   To read the full blog, click the link below: https://bit.ly/3PrWgWV At HRW, we are continually expanding our team’s capabilities in neuroscience, through input and consultancy on research projects; external activities such as conference attendance, webinars, and podcasts; and interviewing expert physicians and researchers within the neuroscience field. To find out more about our work and the team, reach out at hrw_synapse@hrwhealthcare.com #migraines #migraine #migraineawarenessmonth #neurocondition #neuromodulation #neuroscience #neurology #migrainetreatments #migraineadvancements #pharma #pharmaceutical #healthcare #health #healthcaremarketreseaech #marketresearch

I‘d like to add No5 from the references of this post: „The timely diagnosis of #inherited #metabolic disorders (IMD) is essential for initiating treatment, prognostication and genetic testing of relatives. Recognition of IMD in adults is difficult, because phenotypes are different from those in children and influenced by symptoms from acquired conditions. This systematic literature review aims to answer the following questions: (1) What is the diagnostic yield of #exome/ #genome sequencing (ES/GS) for IMD in adults with unsolved phenotypes? (2) What characteristics do adult patients diagnosed with IMD through ES/GS have?... ES and/or GS is likely to yield an IMD diagnosis in adult patients presenting with an unexplained neurological phenotype, as well as in patients with a phenotype involving multiple organ systems. If a gene panel does not yield a conclusive diagnosis, it is worthwhile to analyze all known disease genes. Further prospective research is needed to establish the best diagnostic approach (type and sequence of metabolic and genetic test) in adult patients presenting with a wide range of symptoms, suspected of having an IMD." Ferreira, Elise A., et al. "Inherited metabolic disorders in adults: systematic review on patient characteristics and diagnostic yield of broad sequencing techniques (exome and genome sequencing)." Frontiers in Neurology 14: 1206106. https://lnkd.in/eKjz6rWV

Excited to share our latest research on the clinical profile and factors associated with mortality and poor hospital outcomes in Guillain-Barré Syndrome (GBS) patients. Check out the full paper to learn more about our research and its implications. . #GBS #Neurology #ClinicalResearch #Ethiopia #Healthcare #MedicalResearch . https://lnkd.in/e-cyKF7w

#Scientists #find a #link #between #increased #headaches and #hotter #temperatures for #individuals with #migraines #Medications #Neuroscience ------ https://lnkd.in/gNrJxr-m ------ As temperatures rise, so do chances for migraine attacks, according to a new study from a team of researchers at the University of Cincinnati College of Medicine, Icahn School of Medicine at Mount Sinai, Errex Inc. and Teva Pharmaceuticals U.S. Inc. "Weather change is one of the most common trigger factors for migraine," says Vincent Martin, MD, director of the Headache and Facial Pain Center at UC's Gardner Neuroscience Institute and UC Health physician. He is the study's lead author and president of the National Headache Foundation. These findings from the study, which looked at use of Fremanezumab and whether it could prevent headaches caused by temperature increases, will be presented at the American Headache Society's 66th Annual Scientific Meeting, June 13–16 in San Diego, California. Produced by Teva Pharmaceuticals U.S.. Inc., Fremanezumab is sold under the brand name AJOVY. It is administered by injection under the skin and is part of a set of monoclonal antibodies that have hit the market in the past six years to treat migraine in patients. This class of drugs blocks a protein known as CGRP (calcitonin gene-related peptide) which is responsible for transmission of pain in the brain and nervous system. Researchers cross-referenced 71,030 daily diary records of 660 migraine patients with regional weather data and found that for every temperature increase of 10 degrees Fahrenheit daily, there was a 6% increase in occurrence of any headache. However, during the time periods of Fremanezumab treatment the association completely disappeared. "This study is the first to suggest that migraine specific therapies that block CGRP may treat weather associated headaches," says Fred Cohen, a study co-author and assistant professor of medicine at Icahn School of Medicine at Mount Sinai in New York, NY Martin adds that if the results are confirmed in future studies the drug therapy has the potential to help many people with weather triggered migraine. "What we found was that increases in temperature were a significant factor in migraine occurrence across all regions of the United States," says Martin,also a professor within UC's College of Medicine. "It's pretty amazing because you think of all the varying weather patterns that occur across the entire country that we're able to find one that is so significant." Al Peterlin, who retired as chief meteorologist at the U.S. Department of Agriculture and co-author of the study, added another thought "Hippocrates, the father of medicine, believed that weather and medicine were intimately linked," he says. "A couple thousand of years later, we are proving that weather matters in human health." Other authors include Di Zhang,Mario Ortega and Ying Zhang,Ph.D.