Fractyl Health’s Post

🔬✨ In this week's #TechTales post, we highlight our MOF-based nano-shuttle technology and its role in efficient drug delivery. Drug delivery involves several complex steps to ensure the therapeutic agent reaches its target effectively. Our drug-loaded #NanoShuttles first target and bind to specific cell types. Once the delivery system is bound to the cell surface, the cell internalises it through a process called endocytosis. The delivery system then needs to escape the endosome to release the drug into the cytoplasm. Slow drug release is another essential aspect of our technology. By controlling the release of the drug, we avoid the burst effect, which can lead to rapid, uncontrolled drug release, causing side effects and reduced efficacy. Controlled release ensures steady therapeutic levels over time, enhancing treatment effectiveness and patient outcomes. Stay tuned for our next #TechTales post as we continue to explore the science driving our innovations. 🚀🔗 #DrugDelivery #Nanotechnology #Biopharma #Biotech #HealthcareRevolution

We are thrilled to announce that we have been awarded a grant by Innovate UK via the Future Economy Investor Partnerships SME program. The objective of the grant is to scale-up manufacturing capability for allogeneic cell therapies. There is a huge pipeline of therapies predicted to enter the market in the next decade but the industry is lacking the vital tools and technologies to meet forecast demand. As experts in continuous processing of adherent cells, this grant will permit the development of a scalable, cost effective, and reproducible method of expanding hiPSCs for use in therapy development and manufacturing. A huge thanks to Innovate UK and Northstar Ventures UK for their support. #cellmanufacturing #celltherapy #biomanufacturing #cellculture #bioprocessing #processautomation #biosciences #biotechnology #biopharma #pharma #biotech #innovation #biotechnology #bioengineering #celltherapies #ukrinews # innovateuk

How can we takle the Valley of Death in ATMP development? Creating bridges between Basic research, Clinical research, Biotech and Pharma. Promoting Advanced Bio-Therapies access to patiens worldwide. #adtherapies24 #ATMPS #Biologicals #Biotech #BioPharma #Inovation #Health #Research #Clinic #GAPBioMed #AdvancedTherapies

🔬 𝐔𝐬𝐞 𝐜𝐚𝐬𝐞𝐬 𝐟𝐨𝐫 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡-𝐠𝐫𝐚𝐝𝐞 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞𝐬 🚀   Why do we need research-grade molecules when clinical-grade options are saving time and money in pre-clinical research? Dr. Benjamin Müller, CEO and co-founder of the (bio)analytical company Biofidus AG, sheds light on why these molecules are on the market and what role they may play in advancing drug development projects. 🌱   #BioPharma #DrugDevelopment #InnovationInResearch #ResearchMolecules #EvidenticInsights #BioTech #HealthcareInnovation #ClinicalVsResearch #UnlockingPotential 🧪🔍🌐📊🚀

📢Gilead Sciences Ditches Oceanside Expansion for Foster City ⭐ Gilead Sciences has cancelled its plans to expand its Oceanside facility and will instead move biologics production to Foster City. ⭐ #BioprocessUpdates #GileadSciences #OceansideExpansionCancelled #BiologicsProduction #FosterCity #PharmaceuticalIndustry #HealthcareNews #DrugDevelopment #ResearchAndDevelopment #Biotechnology #Medicine #Science #BusinessNews #CompanyUpdate #GileadMoves #FacilityExpansion ▷ Read the full article here: 📎 https://lnkd.in/dDuGhSbF

With just 3 days remaining until the highly anticipated 19th Annual Drug Discovery Chemistry conference commences in sunny San Diego, CA, from April 1st to April 4th, 2024 ( https://lnkd.in/dgndFQT ), we at Helix are gearing up to fly from our headquarters in Indianapolis to set up shop at Booth 608. With 15 sessions packed into 4 days, the conference offers an ideal platform to explore the latest advancements and insights in drug discovery. We're thrilled at the prospect of meeting you at our Booth 608, engaging in meaningful conversations, sharing the most cutting-edge developments, learning about your research interests, and exploring how we can support you and your projects. We can't wait to see you and chat with you soon! Did you know... Our Cryo-EM and x-ray crystallization services provide clients with the necessary tools to elucidate the structural shape and attributes of their proteins, antibodies, and other biologicals? Success is achieved through the combination of capability, capacity, and expertise. Call us now to discuss how we can assist in bringing your project to fruition! (www.HelixBioStructures.com) #cryoem #crystallization #crystallography #drugdiscovery #drugdesign #protein #proteins #dna #rna #antibody #antibodies #science #nature #research #bio #bionetwork #biotechnology #biotech #bioscience #biotechnologyindustry #biopharma #drugdesign #drugdevelopment #pharmaceuticals #pharma #drug #lifesciences #lifescience

Currently, most drug discovery technologies rely on purified proteins, which greatly limits the efficiency of drug development, resulting in about 90% of disease-related targets being "undruggable". The ChomiX chemoproteomics technologies have revolutionized drug discovery from purified proteins to living cells.   1.The DIA-ABPP platform enables the discovery of novel binding pockets and ligands for endogenous proteins in living cells, especially for undruggable targets that lack structural research. Now the platform has covered more than 10,000 proteins and 40,000 binding sites.   2.The TED-ChomiX platform can identify the direct protein interactions for biologically active molecules in disease-related cells or tissues, and has been widely used in drug target discovery, new mechanism deconvolution and off-target protein profiling. Read on: https://www.chomixbio.com/ #chemistry  #proteomics  #medicine  #biotech #chemoproteomics #undruggable #DrugDiscovery#Pharma

📢 New Video Alert! In this latest video, our CTO, Meina Liang, dives into the #immunogenicity of #ADC drugs, discussing multi-specificity and effective clinical strategies. 💡   It's a must-watch for anyone involved in ADC drug development and clinical research. Don't miss out on this informative resource! Watch the video now and share your thoughts with us.🚀   👉 To learn about Amador's integrated solutions, please contact us: https://lnkd.in/gqWKXmBd   #DrugDevelopment #ClinicalStrategies #PK #Bioanalysis #Biomarker #Innovation

For protein engineers, sequences are at the core of your drug discovery. Highlighting differences in protein sequences shouldn’t be siloed to specialized sequencing tools. Kaleidoscope makes it fast and easy to automatically highlight differences in residues so you can save time switching between different applications and focus on research. Interested? Learn more: https://lnkd.in/gcn2xwd3 #biotech #sciencesoftware #pharma #sciencetools #drugdevelopment #cdmo #therapeutics #proteinengineering

LC–MS/MS-based bioanalysis of proteins continues to advance, driven by ongoing developments in instrumentation, sample preparation techniques, and data analysis strategies. These advancements enhance the capabilities of researchers and regulatory authorities to assess the safety, efficacy, and quality of protein-based drugs. Hear experts Shashank Gorityala and Ben Nie, Ph.D, and moderator @amandahays discuss the principles of hybrid LC–MS methods for large molecule bioanalysis. Case studies on PK and biomarker analysis will be presented to illustrate challenges and solutions. Hosted by @bioanalysis zone. https://bit.ly/3ORFEZB #massspectrometry #bioanalysis #bioanalytical #pharmacokinetics #biomarker #drugdevelopment