European Renal Association (ERA)’s Post

Wondering what role DKK3 plays in chronic kidney disease progression? - Then listen to the new ERA podcast with Danilo Fliser, who explains what DKK3 really is and why its measurement helps to better predict the progression of CKD... *Spoiler* (13:51) We can't answer the first question, but we do have an answer for you to the 2nd! Enjoy listening!

Wondering what role DKK3 plays in chronic kidney disease progression? - Then listen to the new ERA podcast with Danilo Fliser, who explains what DKK3 really is and why its measurement helps to better predict the progression of CKD...

🎙️ Join us in this podcast episode on Hepcidin mimetics! 🎧 Prof Domenico Girelli from University Hospital of Verona (Italy) discusses latest advances on the use of Hepcidin mimetics in the treatment of #PolycythemiaVera and iron metabolism diseases. Listen on major podcast platforms or #EHACampus:

This World Liver Day, we aim to shine a light on the transformative potential of genetics in liver disease management. That’s why we’ve curated a collection of relevant Sano content to drive the conversation forward. 🧬 MASH case studies, whitepapers, reports, podcasts, and webinars – all available now on our blog.👇 https://lnkd.in/e6ZuKpaZ #ClinicalTrials #PrecisionMedicine #WorldLiverDay

Secondary Hyperaldosteronism is a disorder caused by the overactivity of the renin-angiotensin-aldosterone system (RAAS). Patients present with fatigue, weakness, polyuria, and paresthesias, on physical exam, they have hypertension, edema, and tetany from hypokalemia. Diagnosis is based on clinical suspicion, especially in patients with resistant hypertension, and confirmed via laboratory testing. Studies include 24-hour urine aldosterone and plasma renin concentration to confirm, elevated 24-hour aldosterone and high renin levels suggest secondary hyperaldosteronism. Treatment involves potassium-sparing anti-hypertensive agents. Learn more high yield-concepts about Secondary Hyperaldosteronism on our DAILY Medbullets Step 2 & 3 podcast. Listen wherever you listen to podcasts! https://bit.ly/3ZandTw

🎙️CAD deficiency🎙️ - a treatable disorder that’s hard to diagnose CAD is a large, multienzymatic protein required for de novo pyrimidine biosynthesis. Pathological CAD variants lead to a Congenital Disorder of Glycosylation leading to developmental delay and epileptic encephalopathy which is highly responsive to uridine supplementation. CAD deficiency is difficult to diagnose because symptoms are nonspecific, there is no biomarker, and the protein has over 1000 known variants. Herein lies the problem - the management is a relatively simple supplement but the challenge is identifying the patients who will benefit from this. In this podcast, Saskia Wortmann Freeze Hud and Santiago Ramón Maiques discuss the disorder and their work to assess the pathogenicity of 20 unreported missense CAD variants and develop a robust platform to identify the patients who’ll benefit from uridine therapy. Listen on 🍏: https://lnkd.in/eHyH-dNP Or search for #JIMDPodcasts wherever you get your podcasts. #podcast #raredisease #treatment #validation #congenitaldisorderofglycosylation #cdg

#podcast Cynthia Pussinen, CEO of Sernova, describes their innovative cell therapy platform, the Cell Pouch System, which can deliver functional cures for chronic diseases using therapeutic cells, tissues, proteins, and other molecules. This implantable device is made of mesh that allows for vascularization, forming a pseudo-organ that can function in the body and fulfill unmet needs. The current focus is on type one diabetes, where the Cell Pouch has shown promising results, allowing patients to become insulin-independent. Other potential applications include treating hypothyroidism and hemophilia A. #FunctionalCure #CellTherapy #ChronicDiseases #PrecisionMedicine #Medtech Sernova.com https://lnkd.in/gUUmQN6z

The Healthspan Project 🎙️🎧: Episode #3: Learn the utilization of biomarkers for early detection of insulin resistance, such as: -HbA1c -2hr-Insulin/Glucose Tolerance Test -HOMA-IR Then dive into Zone 2, role of carbs and muscle mass to reverse the disease process. Watch below or listen anywhere you get your podcasts. 🎙️🎧 #thehealthspanproject #longevity #healthspan

Long-term brain inflammation in Alzheimer's activates powerful immune molecules like cytokines, increasing beta-amyloid production. Over time, this hinders the brain's ability to clear the harmful clumps of beta-amyloid left behind, posing a significant challenge in the fight against this devastating disease. #HealthBlueprintPodcast #HBPodcast #Podcast #Metabolism #MetabolicHealth #Listen #MentalHealth

Testing for early onset inflammatory bowel disease can not only help establish the diagnosis but also guide therapy. Learn more in this test-specific episode of our "Answers From the Lab" podcast. https://bit.ly/4bbDlJt