Cleveland FES Center’s Post

COSMIIC is seeking #researchers and #startups in adopting a revolutionary implantable device technology 💡 The COSMIIC System has an Investigation Device Exemption (#IDE) from the FDA for use in early feasibility studies (#EFS). COSMIIC is a The National Institutes of Health (#NIH) SPARC.science funded project, new for #NetworkedNeuroprosthesis, device invented to restore muscular functions lost or damaged due to #spinal cord injury. Case Western Reserve University COSMIIC System includes implanted battery, pulse generators, EMG-recording modules, and modules for targeted treatments currently in development. COSMIIC is a major resource enabling translational #neuromodulation data collection, form regulatory pathways, and design new experiments with less resources. COSMIIC newsletter https://lnkd.in/eMy4kbKp.   #neuromodulation #research #biomedicalengineer

A piece of glass developed by a Finnish biotech company turbocharges the capabilities of standard lab microscopes.   Achieving results in observing cellular structures under a microscope has previously required a bleaching process to amplify the cell signal. However, this approach has significant drawbacks. The bleaching process reduces the cell’s lifespan, which limits observation time critical for assessing cell activity and conducting tests. Xfold Imaging Oy Imaging manufactures a specially designed glass for Surface-Enhanced Biomedical Imaging, which can be seamlessly integrated into most laboratory microscopes without needing expensive equipment upgrades or modern replacements. According to Xfold Imaging, this method can exceed the capabilities of the latest (multi-million euro price-tagged) lab equipment, which opens up new possibilities for studying cellular structures and bio-molecules at a nano-scale resolution for a fraction of what it would normally cost. This unprecedented level of depth in observation holds the promise of earlier diagnostics to curb disease outbreaks, provides enhanced insights into diseases, and empowers pharmaceutical companies to develop more effective drugs. Originating as a spin-out from Aalto University, Xfold Imaging is built on research that was led by Xfold Imaging co-founder and CEO Nagarajan Subramaniyam Subramaniyam, in collaboration with Biomedicum Helsinki. Image sourced from https://xfoldimaging.com/ #biotechnology #diagnostics #medtech #diseasedetection #bioimaging

Xfold plasmonic plastic sheets can be easily integrated into various bioimaging and diagnostic applications

🔍 Ever wondered how Point-of-Care in vitro diagnostics (PoC IVDs) revolutionise healthcare? They are medical tests and diagnostic procedures that are performed near or at the location where a patient is receiving care, rather than sending samples to a centralized laboratory for analysis. 🔬 🩺 The term "in vitro" means that the tests are conducted outside of the patient's body, typically using samples such as blood, saliva, etc. 🔗 Learn more here: https://lnkd.in/d7jZxxzZ #2dbiopadproject #horizoneurope #alzheimerdisease #innovation #graphene #nanomaterials #IVD #invitrodiagnostics Palacký University in Olomouc | Czech Advanced Technology and Research Institute | RCPTM - Regional Centre of Advanced Technologies and Materials | Q-PLAN INTERNATIONAL | Institut Català de Nanociència i Nanotecnologia (ICN2) | Grapheal | Aristotle University of Thessaloniki (AUTH) | NOVAPTECH | University of Eastern Finland | Alzheimer Hellas (Greek Association of Alzheimer’s Disease and Related Disorders) | Evnia | Central Institute of Mental Health | CeADAR Ireland | Graphene Flagship

🔬NBIC Proof of Concept funding supported a collaboration between University of Southampton researchers Dr Sandra Wilks and Prof Mandy Fader and medical device company, Nanovibronix (NASDAQ:NAOV) to research a solution to reduce adverse effects caused by catheters. ℹ️ The project shows the effect of the UroShield™ CEmarked device on bacterial populations in patients with indwelling urinary catheters. An evaluation was conducted to assess any changes to the catheter-associated microbiome in order to understand the impact of the UroShield™ on the biofilm community. Patients were also interviewed to understand the impact of using the device on quality of life. Read our case study to find out more 🔎 https://lnkd.in/e5aTeQtu #BiofilmWeek #biofilm #biofilms #humanhealth #nhs School of Healthcare Enterprise and Innovation, University of Southampton

🌟 Exciting Breakthrough in Cardiogenic Shock Research! 🌟 We're thrilled to share our latest achievement: the publication of “Validation of a Multiscale Computational Model Using a Mock Circulatory Loop to Simulate Cardiogenic Shock.” This groundbreaking study, a collaboration with the FDA’s Luke Herbertson and Gavin D'Souza, has made it to the cover of the ASAIO Journal's December issue! Why is this big news? 🚀 Our work tackles the complex challenge of cardiogenic shock (CS) by developing a computational model that sets new standards in precision and reliability. By rigorously aligning with ASME V&V20 and V&V40 guidelines, our model stands at the forefront of innovation and regulatory acceptance. What makes our model stand out? 🔍 It's not just about simulating the hemodynamics of CS. We're pushing boundaries in medical research and device testing. Our model expertly maps how variations in factors like vascular tone and ventricular activity (tough to monitor in real life) influence health outcomes, paving the way for better diagnostics and treatments. Looking ahead, the possibilities are limitless. This isn't just a leap forward in clinical settings; it's a game-changer for R&D in new drug development and medical device testing. The insights gained here are crucial for understanding how innovations impact physiological responses and potential side effects. And the best part? This is just the beginning. We're on a mission to revolutionize cardiogenic shock treatment and analysis, and we invite you to join us on this journey of innovation, excellence, and impact. #CardiogenicShock #HealthcareInnovation #FDA #MedicalResearch #ComputationalModeling #computationallife #healthcare #biotechnology #digitalhealth #healthtech #computerscience #lifesciences #biotech #cfd #cardiovascular #simulation #mathematics #medicaldevices #ICU #MCS #LVAD #digitaltwin

🚀 Exciting news! 🌟 The first call of the year for accessing the cutting-edge equipment at ReDIB is now OPEN until April 30th! ------ Would you like to use the facilities of CIC biomaGUNE with economic advantages? ✅ Available equipment includes: #cyclotron, #radiochemistry lab, PET-CT, SPECT-CT, high-field #MRI (11.7 and 7 Tesla) and dedicated #animal #facility for small rodents. 🎯 The #infrastructure has been designed, built and equipped to tackle longitudinal and multimodal pre-clinical projects and to develop applications in the area of #Preclinical #Molecular and #Functional #Imaging and #Nanomedicine. ------ 👉 REQUEST https://bit.ly/3xw9A72 BRTA - Basque Research & Technology Alliance Universidad Complutense de Madrid ICTS BioImagen Complutense - BioImaC CNIC - Spanish National Center for Cardiovascular Research / Centro Nac. Investigaciones Cardiovasc., Instituto de Investigación Sanitaria La Fe. . #science #ciencia #research #investigacion #knowledge #conocimiento #ICTS #ICTSNew

🚨🚨🚨News!! ICFO and VITALA Technologies awarded with more than 700K€ within the frame of a “Proyecto en colaboración público-privada 2022” The new project, called “SEE-13-MRI – Scope and Efficiency Extended 13C Magnetic Resonance Imaging", is funded as part of the “Proyecto de Colaboración Público-Privada 2022” by the Ministerio de Ciencia, Innovación y Universidades and Agencia Estatal de Investigación. The project will provide a two-fold approach to widen what clinicians and researchers are able to “see” using 13C MRI: VITALA will work on new routes to produce hyperpolarized tracer metabolites with long lifetimes, while ICFO will focus on techniques to continuously and non-destructively monitor their polarization using quantum sensors. Combining these technologies seek to widen access to early detection of disease and break barriers towards future commercial exploitation of HP-13C imaging in preclinical and clinical stages of drug discovery. The “Proyecto de Colaboración Público-Privada” program is part of the Spanish Research, Development and innovation program that is oriented to the challenges facing society. We celebrate this collaboration and hope to create solid results that create high value for the hyperpolarized field and drug testing community! Special thanks to Michael Tayler, Morgan Mitchell, Irene Marco-Rius Maria Alejandra Ortega Machuca Jose Luis Muñoz Gomez, and all their team members for making it possible and a special mention to our collaborators FI Group for managing the submission and office management in the project! #collaboration #startup #research #drugtesting #qualitycontrol #hyperpolarization

Within 15 minutes, the PETAL (Paper-like Battery-free In situ AI-enabled Multiplexed) sensor patch can provide a more comprehensive look at a wound’s healing status, potentially easing the burden of patients and clinicians alike 🏥 Co-developed by the National University of Singapore (NUS) and A*STAR’s Institute of Materials Research and Engineering (IMRE) in collaboration with Prof David Becker’s team at the Skin Research Institute of Singapore (SRIS), the PETAL sensor patch resembles a pinwheel flower—with each petal acting as a sensing region for indicators like temperature and uric acid. The sensor patch is roughly the size of a Lego piece yet it is capable of differentiating healing and non-healing chronic and burn wounds with an accuracy level of up to 97 percent. Moreover, it can be reconfigured to detect different biomarkers, extending its application for other wound types. 💡 Building on the success of their study, the researchers have filed an international patent for their invention and are taking the next steps to advance to human clinical trials. Check out the links below to view The Straits Times feature on their work and the full study published in Science Advances ⬇️ --- #SRIS #skinresearch #skin #research #science #technology #scicomm #innovation #woundhealing #woundcare #woundresearch #chronicwounds #wound #collaboration #InTheNews

📢 A new Bioengineering MDPI Special Issue "Advanced Assessment of Medical Devices" is now open for submissions! 🥼 This Special Issue is guest-edited by Dr. Rob Beadling, Prof. Michael Bryant, and Prof. Richard Hall. 💡 The preclinical assessment of implantable medical devices is essential for enhancing both their safety and efficacy before reaching the patient. This Special Issue aims to showcase device development and assessment that goes beyond the current state of the art by inviting contributions from the community in the following areas (among others): 👉 Advanced preclinical testing; 👉Device–biology interaction; 👉Co-creation with patients, clinicians, regulators, and industrial partners; 👉Machine learning and in silico digital twin methodologies; 👉Predictive models for device behaviour in vitro and in vivo; 👉High-throughput methodologies for biomaterial characterisation; Regulatory science. 🔗 Click the link to access more details about the Special Issue: https://lnkd.in/gD6nYStW 🕑 The deadline for manuscript submissions is 30 November 2024. 🎉 #medicaldevice #medicalengineering #hipreplacement #preclinicaltesting