Cell & Gene’s Post

Transplanted retinal cells offer hope for treating age-related vision degeneration. Researchers in Singapore have made a breakthrough in the treatment of Age-related Macular Degeneration (AMD), a leading cause of blindness in the elderly. By studying the genetic behavior of individual transplanted retinal pigment epithelial (RPE) cells using single-cell RNA sequencing technology, they discovered a subpopulation of RPE cells that closely resemble healthy adult human RPE cells. These cells express genes that support vision and promote cell survival. This discovery could lead to improved therapies for AMD and other eye conditions. Read more: https://lnkd.in/d28JVa3a #eyehealth #rna #amd #medical #disease #treatment

Peering into the world of cells to create a brighter future. Using in vitro methods, Ritika S. is harnessing the power of haematopoietic stem cells—pioneers in blood cell production. Her objective? To generate an alternative and accessible source for transplants, tackling long waiting lists, donor shortages and immunocompatibility issues head-on, while illuminating new pathways for studying human blood development and genetic diseases. #StemCellResearch #ScienceForABetterWorld Learn more about her research here: https://lnkd.in/gvdKyzW4 #MagnifyAU #STEMSisters #bloodcellresearch #haematopoieticstemcells #transplants

New research from the Weizmann Institute of Science identifies a protein, PTBP1, previously thought to be expressed only during embryonic development, as a key factor in regenerating adult neurons in the peripheral nervous system. Unlike the central nervous system, which struggles with regeneration, the peripheral nervous system, connecting the brain and spinal cord to organs, efficiently regenerates due to PTBP1. The study reveals that PTBP1 levels rise after nerve cell injury, binding to RNA molecules involved in regeneration, particularly influencing the RHOA control molecule, suggesting a potential avenue for treating neurodegenerative diseases. #NeuroRegeneration #PeripheralNervousSystem #NeurodegenerativeDiseases Stefanie Alber | Pierluigi Di Matteo | Mike Fainzilber

Using long-read RNA sequencing, we found that in iPSC-derived dopamine neurons, 10% of SNCA expression encodes novel open reading frames. We discovered that these novel open reading frames are expressed, and a subset of them are translated in the brain. More importantly, we demonstrate that understanding the 3' UTR structures of SNCA enabled the targeted design of antisense oligonucleotides, which reversed key Parkinson's disease pathologies. #Parkinsons #SNCA #ASO

NYU Langone Health is pushing the boundaries of medical science with their pioneering xenotransplantation procedures, transplanting genetically modified pig organs into humans. This includes the world's first pig kidney transplant into a living patient in 2024! 🐖➡️🧬 New groundbreaking studies published in Med and Nature Medicine reveal how these transplants impact the human body at the cellular level, utilizing advanced techniques like single-cell RNA sequencing. Discoveries show subtle immune reactions that may challenge long-term success but also provide crucial insights for future enhancements in transplant compatibility and patient treatment strategies. This isn't just a step forward in medical science; it's a leap towards redefining life-saving procedures! #MedicalInnovation #Xenotransplantation #NYULangoneHealth #FutureOfTransplants 🌐💉

A link between genetic risk factors for Alzheimer’s disease (AD) and microglial lipid droplet accumulation was recently discovered. Several genetic risk factors for AD implicate genes involved in lipid metabolism, many of which are highly expressed in glial cells. However, the relationship between lipid metabolism in glia and AD pathology remains poorly understood. Using single-nucleus RNA sequencing of brain tissue from AD patients, the scientists identified a microglial state characterized by the lipid droplet-associated enzyme ACSL1 expression. ACSL1-positive microglia are most abundant in patients with the APOE4/4 genotype. In human-induced pluripotent stem cell-derived microglia, fibrillar Aβ induces ACSL1 expression, triglyceride synthesis, and lipid droplet accumulation in an APOE-dependent manner. Furthermore, the researchers demonstrated that conditioned media from lipid droplet-containing microglia led to Tau phosphorylation and neurotoxicity. Vist us at https://treventis.com/ #Alzheimersdisease #microgila #APOE #lipid #stemcell https://lnkd.in/geBphQwi

Did you know that early detection of genetic predispositions to diseases is possible through stem cell storage? Advanced genetic screening not only identifies potential health issues before symptoms appear but also paves the way for personalized medical treatments. We’re beyond excited to say that today, at this very moment, stem cell technology is revolutionizing preventive care. Want to know how it can help you? Let's start the conversation. ➡️ https://lnkd.in/e-EJCeqc #earlydetection #earlydetectionsaveslives #earlydetectionmatters #yourhealthmatters #healthiswealth #prevention #preventivehealth

#neurodegenerativedisease #kinase #synapticremodeling #synapticdysfunction c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases https://lnkd.in/grgQnAFJ Our ability to learn and remember depends on the active formation, remodeling, and elimination of synapses. Thus, the development and growth of synapses as well as their weakening and elimination are essential for neuronal rewiring. The structural reorganization of synaptic complexes, changes in actin cytoskeleton and organelle dynamics, as well as modulation of gene expression, determine synaptic plasticity. It has been proposed that dysregulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative diseases. Much is known about downstream signaling of activated N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoazolepropionate receptors; however, other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and memory. The non-receptor tyrosine kinase c-Abl (ABL1) is a key signal transducer of intra and extracellular signals, and it shuttles between the cytoplasm and the nucleus. The present review has been designed to elucidate the common links between c-Abl regulation of structural changes that involve the actin cytoskeleton and organelles dynamics, and the transcriptional program activated during synaptic plasticity. By summarizing the recent discoveries on c-Abl functions, we aim to provide an overview of how its inhibition could be a potentially fruitful treatment to improve degenerative outcomes and delay memory loss.

👩🔬 BMKGENE provided bulk RNA sequencing and analysis services for this study: Wound infiltrating adipocytes are not myofibroblasts. 🧬 The article was published in Nature Communications 📚 , it explores the potential plasticity of adipocytes and fibroblasts after skin injury🤕️. Using genetic lineage tracing and live imaging in explants and in wounded animals, observe that injury induces a transient migratory state in adipocytes with vastly distinct cell migration patterns and behaviors from fibroblasts. 🔑 Furthermore, migratory adipocytes, do not contribute to scar formation and remain non-fibrogenic in vitro, in vivo, and upon transplantation into wounds in animals. In summary, the injury-induced migratory adipocytes remain lineage-restricted and do not converge or reprogram into a fibrosing phenotype. These findings broadly impact basic and translational strategies in the regenerative medicine field, including clinical interventions for wound repair, diabetes, and fibrotic pathologies. #BulkRNAsequencing #WoundInfiltratingAdipocytes #RegenerativeMedicine #Myofibroblasts #Publication

Dear #multiomics friends!☕️ Great paper from Eric Verdin, Shinya Yamanaka and their teams! 👏👏👏 https://lnkd.in/dkpFHzeF #multiomicspapers challenge! 💡💡💡💡💡💡: ☑️miRNAs regulate SIRT1 expression during embryonic stem cell differentiation ☑️SIRT1 is a deacetylase that targets histones and a variety of other proteins also connected to autophagy. ☑️SIRT1 regulates the aging process via different mechanism of actions: suppression of cytokine expression (inflammation), regulation of genome stability via microsatelite and CpG island methylation status,autophagy,… ☑️Resveratrol, a plant polyphenol, exhibits antiaging, antitumor, and vascular protection effects by activating Sirt1 ☑️ a great study (EMPEROR trial) has recently shown that SGLT2i have a great effect on heart failure via regulation of autophagy and SIRT1 expression.. Great way to go and I am sure new studies will elucidate in details the effects of these molecules in different disease areas! #olinkproteomics #epigenetics #aging #agingresearch