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🚨 New content coming soon! ⏰ This review from Anita Ghodsi, Andres Hidalgo and Stephania Libreros from Yale University focuses on recent advances in understanding the many functions of specialized pro-resolving mediators in neutrophil biology, from expediting neutrophil apoptosis, promoting clearance by macrophages, regulating their excessive infiltration at inflammation sites, to coordinating bone marrow deployment. You can check this out now online at the link below, published ahead-of-print! https://ow.ly/G3Ny50REyA7 Or make sure you are subscribed to our eTOC alert to be the first to know when our next issue is published! Visit the homepage for links to subscribe. Scroll down on our feed for screenshots of where to find these, or drop a comment below if you need a hand. 😀 Happy reading!

The July issue of Current Opinion in Hematology is here! 🙌 Read the final version of this paper, Lipid mediators in neutrophil biology: inflammation, resolution and beyond, along with others in the Hematopoiesis section update from Maegan Capitano 👇 https://ow.ly/QV8550S1YvX ⭐ The role of hematopoiesis in bone repair: an update ⭐ The impact of obesity-induced inflammation on clonal hematopoiesis ⭐ Epigenetics of hematopoietic stem cell aging #hematology #hematopoiesis #reviews

[Latest scientific papers] In our latest issue, the study "Synthesis and protective effect of pyrazole conjugated imidazo[1,2-𝘢]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and apoptosis" by authors Binbin Zang and Lihui Wang was published. In this work, the authors have synthesized various pyrazole-conjugated imidazo[1,2-𝘢]pyrazine derivatives. These compounds were then tested against acute lung injury in rats with sepsis and their mechanism of action was proposed. A wide range of NF-κB inhibition was observed with subsequent reduction of oxidation stress and pro-inflammatory cytokines which in turn led to positive histopathological changes in treated lungs. Check the paper on: https://lnkd.in/dFNTDerB

📖 Very happy to share a new article entitled "Effects of personal exposure to the oxidative potential of PM2.5 on oxidative stress biomarkers in pregnant women"! This study was published in Science of the Total Environment (STOTEN) (and accepted literally during my PhD defense)! The following link provides free access until January 14, 2024: https://lnkd.in/esf6yNBX 💡 In this study, a consistent pattern of association was found between personal exposure to the oxidative potential of PM2.5 and a urinary biomarker of oxidative stress to DNA in a population of pregnant women from the cohort SEPAGES (https://lnkd.in/eX3gcrmX). These findings further support the use of PM oxidative properties to estimate exposure to air pollution.

✨✨ Welcome to read the latest research "Tuning the molecular structure of corroles to enhance the antibacterial photosensitizing activity" by Dr. Daniel A. Heredia et al. 🔗 Paper link: https://shorturl.at/Apgmw The manuscript describes the design and synthesis of four corrole derivatives with different substitution patterns and how they can influence in the efficacy of photodynamic inactivation of pathogens. The studies demonstrate that even though the photophysical and photodynamic properties of these phototherapeutic agents were retained regardless of the external derivatization of the macrocycle, a remarked influence was found in PDI treatments against methicillin-resistant Staphylococcus aureus and Klebsiella pneumoniae. It is worth mentioning that a large number of photosensitizers have been investigated to photoinactivate a broad spectrum of microbes; however, the literature has very few reports using corroles. As far as we know, this is the first time that a PDI study has been carried out using corroles with different substitution patterns and precursors of positive charges (by protonation of their tertiary amines at physiological pH). The non-charged corrole with three precursors of cationic centers exhibited the highest PDI action, showing outstanding levels of microbial inactivation, being an effective broad-spectrum antimicrobial photosensitizer. We consider that this manuscript addresses a significant advancement in this family of tetrapyrrolic macrocycle.

In today's edition of "Did you know..." In the dynamic world of research, innovation knows no bounds. This blog post delves into the intriguing off-label uses of Vascular Access Buttons™. It's not just for mice and rats anymore! Discover how scientists are harnessing the potential of this versatile tool beyond its initial scope, opening up new avenues for researchers. From ferrets to rabbits to minipigs, these unconventional methods have opened up new possibilities in the scientific community, changing the way we think about vascular access. Dive into the full article and see publications here: https://hubs.ly/Q026Mbkl0

The Autophagic Punctum I wrote with my mentor, Andreas Jenny, and in collaboration with Gustavo Macintosh was just published! In this publication, we briefly discuss the complexity of lysosomal pH regulation, which will be the focus of my studies in the coming years. https://lnkd.in/ef-Kje7a

And it's out! Our latest manuscript describing the intricate relationship between UV radiation and urban particulate matter in human dermal fibroblasts has just been published in Aging Cell.  In this study, we show that treating fibroblasts with subcytotoxic doses of UVA/UVB leads to mitochondrial dysfunction, increased ROS levels, and DNA damage. Interestingly, simultaneous UPM treatment of UV-irradiated cells selectively inhibited autophagic flux, altering the fate of a fraction of the cell population from senescence to apoptotic cell death. Our findings emphasize the need to consider both environmental stressors when assessing mechanisms of extrinsic skin aging. Read the full manuscript at:https://lnkd.in/dZdE7h5W

➡️ I am really excited to see the first publication of the EDASP cohort. ➡️For the last 5 years, I´ve been pushing really hard as its principal investigator to make this independent cohort study a reality. ➡️This work would not have been possible without the invaluable support of amazing and generous collaborators and friends such as Nehal Mehta Joel M Gelfand MD MSCE Maru G. Barderas Leticia Fernandez Friera Jorge Solis Martin Carlota B. Abbad-Jaime de Aragón @Emilio Berna ➡️The EDSAP study aims to identify new molecular and imaging markers associated with the presence of atherosclerosis and its progression in psoriasis and the evaluation of the impact of antiinflammatory therapies in athero. First papers comming soon!!!! #psoriasis #research #atherosclerosis #comorbidities

We are pleased to share this new publication on characterization of EGFR and specific mutation signaling biases using RTK biosensors. Thanks to our partners! #drugdiscovery #oncology #oncologyresearch