Jnana Therapeutics is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-todrug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune mediated diseases. Jnana's wholly owned lead program, JNT-517, which targets an allosteric site on the phenylalanine transporter SLC6A19, is a potential first-in-class oral approach for the treatment of PKU, a rare genetic metabolic disease. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, a highly experienced management team, and the backing of leading life science investors Bain Capital Life Sciences, RA Capital Management, Polaris Partners, Versant Ventures, Avalon Ventures, Pfizer Ventures, and AbbVie Ventures. For more information, please visit www.jnanatx.com and follow us on Twitter/X and LinkedIn.
At Jnana, you join a diverse, ambitious, and passionate team dedicated to making substantial advancements for patients across a variety of diseases. The culture at Jnana is one of collaboration and urgency, driven by a shared purpose to deliver innovative therapies for the most challenging targets. Our team's quality and the cutting-edge nature of our science are what make Jnana a great place to work every day – and a place where you belong!
About the Opportunity
Join our dynamic senior leadership team in our mission to develop first- and best-in-class therapies that address unmet medical needs through cutting-edge science and collaboration! As our Vice President/Senior Vice President, Head of Clinical Development, you'll spearhead our groundbreaking clinical program, guiding our flagship PKU program, JNT-517, through pivotal trials. Leveraging our innovative RAPID platform, you will drive the development of therapies with the potential to transform patient outcomes in rare diseases and immune mediated diseases.
Reporting to the Head of Development, your scope will include leading our clinical programs, providing leadership of the clinical development teams, developing and pressure testing clinical development programs and their successful delivery, while ensuring adherence to regulatory standards. You will serve as a key leader within the company, building and developing internal teams, collaborating with external partners and stakeholders, including key opinion leaders, patient groups and our Board of Directors. This position requires an MD and a robust track record in biopharmaceutical clinical development, particularly in navigating complex regulatory environments and leading innovative drug development projects.
Responsibilities
Provide strategic leadership and direction for all clinical development programs, ensuring alignment with company goals and regulatory requirements.
Pressure test novel development strategies to rapidly de-risk assets and accelerate development.
Direct the planning, delivery, and leadership of clinical trials from early to late phases.
Lead the development and refinement of clinical trial protocols, ensuring scientific rigor, ethical considerations, and compliance with regulatory guidelines.
Assume medical and clinical accountability throughout the clinical trial lifecycle, including safety monitoring, data interpretation, and risk management.
Develop and implement robust regulatory strategies to facilitate successful clinical trial approvals and submissions.
Build and cultivate a high-performing clinical development team, promoting a culture of collaboration, innovation, and excellence.
Act as the primary liaison for clinical development activities with external stakeholders, including investigators, key opinion leaders (KOLs), regulatory agencies, and strategic partners.
Identify and mitigate potential risks and challenges associated with clinical trials, implementing proactive strategies to optimize trial outcomes.
Direct data analysis and reporting activities, providing strategic insights to support decision-making and regulatory submissions.
Present clinical development updates, strategic plans, and trial outcomes, including to the company's Board of Directors and executive leadership.
Preferred Qualifications
Medical degree (MD, DO, MBBS, MBChB, MBBCh) is highly preferred. PhD/PharmD candidates may be considered on an exceptional basis.
Extensive clinical development experience within the biotechnology or pharmaceutical industry, with hands-on experience leading teams to lead progression of drug candidates through early/late development and regulatory submission.
Deep understanding of global regulatory requirements and successful track record of navigating clinical trials to approval, particularly within the US and EU.
Demonstrated experience in senior leadership roles, managing large-scale clinical development programs, and leading multidisciplinary teams.
Seniority level
Executive
Employment type
Full-time
Job function
Business Development and Sales
Industries
Technology, Information and Internet
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