Sr. Scientist, Chemistry

DIRECT HIRE

MUST HAVES:

• PhD in analytical, organic chemistry or a related discipline
• Minimum of 2 years of direct experience in oligonucleotide analysis and formulation
• Experience in the biotechnology and/or pharmaceutical industry is preferred, with direct experience with (semi)automated instruments
• Strong method development skills including experience with liquid chromatography, capillary electrophoresis and mass spectrometry techniques

Job Summary

We are seeking a dynamic scientist who has extensive experience in the analysis of oligonucleotides to support pipeline production and characterization of oligonucleotides. The successful candidate will be responsible for characterizing siRNA and other nucleic acid structural forms with multiple analytical techniques, including liquid chromatography and high-resolution mass spectrometry (HR MS). The individual will focus on developing and executing LC-MS-based assays to support lead finding/optimization efforts. In addition, the candidate will function as part of a multi-disciplinary project team that will coordinate with scientists in cross functional areas to advance the lead molecules. In addition, this scientist will collaborate with a cross-functional team of experts to focus on the development and optimization of CASi candidates, as well as supervising and supporting junior team members.

This is a full-time position reporting to the Vice President of our Chemistry team. The position requires on location work in our South San Francisco office.

Responsibilities

• Design and execute experiments to fully characterize the oligonucleotide drug substance and drug product materials.

• Demonstrate proficiency with analytical characterization techniques (e.g., mass spectrometry, liquid chromatography, UV/Fluorescence, and electrophoresis)

• Ability to independently conceive, develop, execute, and then implement novel/advanced scientific techniques. Holistic thinker for analytical packages.

• Report at project team meetings, write analytical development reports, provide recommendations

to management.

• Manage and support junior team members.

• Collaborate with internal and external manufacturing partners to develop robust analytical

methods.

• Participate in multidisciplinary teams including Biology (in vitro and in vivo pharmacology), and

Chemistry (production, analytical sciences, and platform chemistry groups) - Present results through team meetings and recommendations to management.

• Deliver innovative solutions using a diversity of thought and experiences.

• Ensure the quality of each delivered entity.

• Maintain lab notebooks, report data with analysis of results in presentations and/or written reports to the scientific team.

Required Qualifications

• PhD in analytical, organic chemistry or a related discipline

• Minimum of 2 years of direct experience in oligonucleotide analysis and formulation.

• Experience in the biotechnology and/or pharmaceutical industry is preferred, with direct experience with (semi)automated instruments.

• Strong method development skills including experience with liquid chromatography, capillary

electrophoresis and mass spectrometry techniques.

• Proficiency with Chromeleon, Xcalibur and Biopharma Finder is preferred.

• Experience with managing project teams in a biotechnology organization is preferred.

• A history of authoring publications and/or study reports.

• A deep commitment to working as part of teams to deliver breakthrough medicines.

• Excellent communication, organization, and time management skills and ability to work both

independently and collaboratively.