Scientist, Platform

Elsie is looking to hire a Scientist, Platform Development to join its research team in San Diego, California to help push the development of Elsie’s proprietary ultra-high throughput discovery platform. About Elsie: Founded in 2021, Elsie aims to develop optimized oligonucleotide therapeutics for treating severe human diseases. Elsie has introduced several cutting-edge technologies, including an ultra-high throughput screening platform and innovative oligonucleotide chemistry solutions, to advance this mission. In 2024, Elsie was acquired by GSK, and still operates independently as a wholly owned subsidiary. Elsie fosters a culture that combines the agility and research focus of a biotech startup with the supportive infrastructure, growth opportunities, and resources of a major pharmaceutical company. GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com. Job Description: Elsie is looking to hire a Scientist to join its research team in San Diego, California to help push the development of Elsie’s proprietary ultra-high throughput discovery platform. This is an ideal position for researcher or technologist with experience in molecular biology or cell biology and an interest in oligonucleotide therapeutics. A candidate that thrives in a team oriented, fast-paced, and cross disciplinary environment will excel at in this position. This candidate will have a hands-on-role contributing to the development of Elsie’s proprietary discovery engine and the integration of in house high-throughput oligonucleotide library synthesis and use capability. Our ideal candidate will bring a wide breadth of experience and interest that may span molecular biology assay development, to next-generation sequencing assay technologies, to a working understanding of oligonucleotide synthesis. This position will work closely with researcher across backgrounds, from organic chemistry to neurobiology, to support and advance Elsie’s drug discovery platform. Responsibilities: Lead the design, analysis, and development of new assays for use in Elsie’s proprietary therapeutic discovery platform using molecular and cell biology techniques Lead the analysis and processing of next generation sequencing data derived from the discovery platform Work collaboratively to ensure that oligonucleotide libraries are fit for purpose to enable high-throughput screening by discovery platform Participate in the pipeline deployment of novel screens to continually enable proprietary therapeutic discovery Work collaboratively to use the discovery platform to create fit-for-purpose data sets to enable Elsie’s AL/ML efforts Operate with excellent cross functional collaboration skills to ensure chemistry, biology, and platform inputs are considered and met Qualifications and experience: Ph.D. in Biochemistry, Chemical Biology, Organic chemistry, or related discipline with experience in oligonucleotide chemistry and molecular biology Experience in assay development techniques, NGS assay development especially of interest Experience with basic oligonucleotide (RNA/DNA) manipulation techniques (ex: OPC, ligations, desalting, nucleolytic degradations) Familiarity with chemically modified oligonucleotides and oligonucleotide synthesis is a plus Familiarity with next generation sequencing procedures, library preparation, and theory is a plus Background in oligonucleotide therapeutic drug discovery is a plus Ability to perform self-directed research with a sense of urgency and positive, can-do attitude Ability and desire to learn and contribute across functional groups Elsie offers competitive compensation and benefits. More importantly, we offer an outstanding opportunity to join, contribute to, grow with, and excel in our dynamic culture. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other protected categories. For immediate consideration, please apply here via LinkedIn or email your cover letter and resume referencing SCI00X to careers@elsiebio.com.