Scientist II, Translational Sciences

The Position

In this dynamic lab-based role at Maze Therapeutics, you will be at the forefront of our efforts to discover and validate biomarkers for multiple programs across the pipeline. You will leverage your expertise to design, execute, and build upon experiments, translating genetic insights into meaningful clinical applications. Collaborating cross-functionally from discovery to clinical sciences this role requires you to think critically about data, analyze results rigorously, and develop innovative experiments that drive our scientific programs forward. Your work will have a direct impact on patients, bridging the gap between preclinical discoveries and clinical development.

Your Impact

• Independently design and execute studies to identify novel biomarker concepts and explore their relationship to drug mechanism of action
• Collaborate cross-functionally contributing biomarker expertise and point of view to large-scale studies and broader scientific initiatives supporting our programs
• Make detailed observations, interpret and analyze data, and communicate results clearly in a variety of settings
• Maintain timely and accurate lab records, adhering to good documentation practices
• Provide scientific expertise in primary research areas while expanding knowledge of related disciplines across the pipeline
• Prepare, review and deliver high quality scientific presentations for both internal and external use
• Contribute to scientific reports and publications, and participate in conferences and academic research collaborations
  
  

Skills And Qualifications

• PhD in translational biology, pharmacology, cell biology, or related science
• Highly curious and creative thinker driven by translating preclinical discoveries into clinical impact
• Demonstrated ability to lead complex studies through cross functional collaboration
• Extensive experience with diverse biomarker assay technologies (including ELISA, proteomics, RNAseq, metabolomics) and proven assay troubleshooting skills
• Extensive experience with cell culture and mouse models of disease
• Pre-clinical and clinical biomarker experience developing assays and contributing to regulatory documents is a plus
• Strong publication record demonstrating the ability to conduct independent research
• Highly motivated, self-starter with excellent written and verbal communication
  
  

About Maze Therapeutics

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases, such as chronic kidney disease, . and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass Platform™, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $131,000 to $160,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.