Director DMPK

We are looking for an enthusiastic and highly motivated Director of DMPK to join our dynamic drug discovery and early development team in San Diego. Reporting to the Executive Director of Preclinical R&D, the successful candidate will work closely with the DMPK, biology, and chemistry teams. This role involves driving early discovery research programs into early clinical development while providing scientific and technical expertise to a internal team of 6 researchers. The role will require about 20% bench work, but also has a work from home component.

The ideal candidate will have extensive experience working in a multifunctional DMPK group, with a deep understanding of various DMPK assays and their application in solving broader project challenges. Additionally, the candidate should have significant experience representing DMPK on multiple project teams and the ability to mentor and train junior team members.

Key Responsibilities:

• Lead and manage in-vivo and in-vitro ADME/PK studies to support drug discovery and early development of small molecules.
• Collaborate with medicinal chemists to design drug candidates that avoid metabolic liabilities and evaluate them based on potency, ADME profile, and drug-drug interaction liabilities.
• Mentor and motivate the in-house DMPK team, fostering a collaborative and proactive environment.
• Evaluate and interpret in vitro and in vivo DMPK data, working with DMPK colleagues to design studies that address key project issues.
• Prepare DMPK documents to support development candidate nominations and regulatory filings.
• Manage and troubleshoot DMPK activities and instrument/assay issues as they arise.

Requirements:

• Doctoral or Master’s degree in analytical chemistry, biochemistry, or a related field with 10+ years (Doctoral) or 15+ years (Master’s) of relevant industry experience.
• Proven ability to work independently in a fast-paced environment as well as in a team setting.
• Strong organizational and reporting skills.
• Experience writing/reviewing nonclinical sections of regulatory submissions.
• Experience contracting/managing CROs for nonclinical studies is a plus.
• Demonstrated ability to manage multiple studies and DMPK activities simultaneously.

We offer a collaborative work environment and the opportunity to contribute to the development of innovative therapeutics. If you are a highly motivated professional with the required experience and skills, we encourage you to apply.