We are seeking a Biologist to support the development of vaccines against HERV-K envelope to treat amyotrophic lateral sclerosis. This role involves immunizing transgenic mice expressing HERV-K envelope under a neuronal promoter with vaccine compounds before clinical symptoms appear, to test the prevention capability of the vaccines.
Education
Bachelor's Degree
Certifications & Licenses
ACUC
Skills
Small animal handling
Laboratory techniques
Data analysis
Tissue preparation
Molecular biology
Software
Microsoft Office
Responsibilities
Animal Handling and Surgery:
Conduct behavioral testing and perform surgery on small animal models.
Perform behavioral assays in association with the primary research project.
Maintain, breed, genotype, and phenotype transgenic animal colonies.
Inspect animals daily for viability and health status.
Handle, dissect, and euthanize animals.
Generate transgenic and knockout cell lines using the microinjection method.
Perform animal surgeries, including utero electroporation.
Prepare animals for surgery, including anesthesia, injection catheters, and physiological monitoring.
Handle experimental animals, including tail vein injections, administration of anesthesia, and monitoring of vital signs.
Tissue Preparation and Analysis:
Harvest and collect animal embryos, tissues, and organs.
Perform tissue fixation, embedding, sectioning, and staining techniques.
Prepare frozen slices and paraffin sections, stained to demonstrate normal and abnormal structures.
Conduct molecular biology techniques, including DNA extraction, PCR, and gel electrophoresis.
Maintain cell lines and perform basic cell culture assays.
Perform immunohistochemistry and analyze experimental data using light and confocal microscopy.
Conduct apoptosis assays, qPCR, Western blotting, and molecular cloning techniques.
Data Analysis and Documentation:
Update and maintain laboratory notebooks and databases.
Collect, analyze, and interpret experimental data.
Prepare reports and manuscripts based on experimental results.
Assist in the preparation of data and images for research presentations and publications.
Document all laboratory procedures, experiments, and results.
If you are passionate about contributing to ground breaking research and possess the required skills and qualifications, we encourage you to apply
Seniority level
Entry level
Employment type
Full-time
Job function
Research, Analyst, and Information Technology
Industries
IT Services and IT Consulting
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