Associate Scientist

We are seeking an Scientist I/Associate Scientist to join our client’s T-cell Receptor (TCR) Discovery team. The incumbent will use state-of-the-art instrumentation and techniques for the identification of TCRs that recognize minor histocompatibility antigens, as well as tumor-associated antigens and neoantigens. Additionally, she/he will work with a group of individuals developing a high-throughput platform that is able to isolate and identify rare antigen-specific T-cells from healthy and patient donor samples. Candidates interested in expanding their knowledge and gaining experience in cell-based (TCR-T) cancer therapies and drug discovery are highly-encouraged to apply.

Duties and Responsibilities may include:

• Process, characterize, and coordinate the genotyping of primary human blood/PBMC samples
• Apply high-throughput cell culture techniques for establishing co-cultures of primary T-cells with antigen-presenting cells
• Transduce and/or electroporate antigen-presenting cells with lentivirus or plasmid constructs
• Analyze T-cells and T-cell receptor function via flow cytometry
• Perform molecular biology techniques as the project requires for the cloning and detailed characterization of TCRs
• Develop assays for high-throughput screening of T-cells and TCR-antigen reactivity
• Maintain accurate sample and laboratory records
• Organize and conduct assigned studies with a high-degree of independence and attention to detail
• Present scientific results to peers and management during regularly scheduled lab meetings

Required & Preferred Qualifications

• PhD in Cancer Biology, Immunology, Cell Biology, Molecular Biology, or related fields is required
• Hands-on research experience in an academic or industry setting is required
• A record of advancing projects, as evidenced by publications or patents is required
• In-depth knowledge of cellular biology is required
• Demonstrated work in cell culture techniques, including designing, setting up, and performing cell-based assays is required
• Experience in T-cell enrichment, expansion, and characterization is preferred but not required
• Previous exposure to flow cytometry is preferred
• Experience in cell line development is preferred
• Experience in assay/platform development is preferred
• Experience in cellular transfection, lentivirus production and transduction is preferred
• Proficiency with analytical software packages, e.g., SnapGene, PRISM, FlowJo, and Excel is preferred
• The ability to adhere to timelines and milestones, in an organized manner, is required
• Excellent communication and presentation skills are highly preferred
• Demonstrated ability to independently identify issues and troubleshoot is required

This job description will be reviewed periodically and is subject to change by management.

NOTE: This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law, including disability/veteran status. This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company’s facilities.

Here is a link to the Job Description on our company website:

https://careers.bioethic.co/#/jobs/181