Associate Scientist

Description:

Associate Scientist / Senior Research Associate – Biology

Role Summary

We are currently searching for an Associate Scientist / Senior Research Associate with experience in cell-based assays and animal management to join the Oligonucleotide team. The successful candidate will help execute and analyze cell-based assays, assist in developing and onboarding new biochemical and cell-based assays, and assist in mouse colony management.

Responsibilities:

• Work in a cross functional team to advance ASO or siRNA knockdown modalities for therapeutic applications.
• Plan and execute experiments to evaluate and optimize oligonucleotide design in cell-based assays.
• Participate in the design and scaling of assays for drug candidate screening in cell based assays.
• Analyze and interpret data from molecular pharmacology studies.
• Assist in mouse colony management and tissue collection.
• Maintain detailed records of experiments.
• Attend and present data at internal team meetings.

Skills and Requirements:

• BS/MS in biology, biochemistry, cellular/molecular biology, or related discipline with 3+ years of postgraduate research experience in an academic or industry setting.
• Experience in cell and molecular biology including mammalian cell culture, mRNA isolation/quantitation by qPCR, sequencing (NGS/Sanger), protein quantification by ELISA and western blot is required.
• Experience with animal colony management, animal handling, in vivo surgeries, and in vivo protocol writing is highly desired.
• Handson experience in working with samples in 96- or 384-well plate format is desired.
• Familiarity with CNS disease models, DNA/RNA editing tools, and oligonucleotide therapeutics is a plus.
• Outstanding aptitude for experimental design and execution, efficient assay development and creative problem solving.
• Capacity to be highly productive in a fluid and fastpaced work environment.

Committed and collaborative team player