West Askew

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Patents

  • Nanodiamond Counting

    Issued US US 14/336,589

    Methods and systems for detecting the locations of individual instances of an analyte (e.g., individual cells, individual molecules) in an environment are provided. The environment includes functionalized fluorophores that are configured to selective interact with (e.g., bind with) the analyte and that have a fluorescent property that can be modulated (e.g., a fluorescence intensity that can be affected by the presence of a magnetic field). Detecting the location of individual instances of the…

    Methods and systems for detecting the locations of individual instances of an analyte (e.g., individual cells, individual molecules) in an environment are provided. The environment includes functionalized fluorophores that are configured to selective interact with (e.g., bind with) the analyte and that have a fluorescent property that can be modulated (e.g., a fluorescence intensity that can be affected by the presence of a magnetic field). Detecting the location of individual instances of the analyte includes illuminating the environment and detecting signals emitted from the fluorophores in response to the illumination during first and second periods of time. Detecting the location of individual instances of the analyte further includes modulating the modulatable fluorescent property of the fluorophores during the second period of time and determining which individual fluorophores in the environment are bound to the analyte based on the signals detected during the first and second periods of time.

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  • Spatial Modulation of Magnetic Particles in Vasculature by External Magnetic Field

    Issued US US14061334

    A method for modulating a response signal includes introducing functionalized magnetic particles configured to interact with target analytes into the body, applying a magnetic field sufficient to draw the functionalized magnetic particles towards a surface of the lumen of subsurface vasculature closest to an internally or externally applied mask having a spatial arrangement, and detecting a response signal, which includes a background signal and an analyte response signal, transmitted from the…

    A method for modulating a response signal includes introducing functionalized magnetic particles configured to interact with target analytes into the body, applying a magnetic field sufficient to draw the functionalized magnetic particles towards a surface of the lumen of subsurface vasculature closest to an internally or externally applied mask having a spatial arrangement, and detecting a response signal, which includes a background signal and an analyte response signal, transmitted from the subsurface vasculature. The analyte response signal related to interaction of the functionalized magnetic particles with the target analytes and is modulated with respect to the background signal due, at least in part, to the spatial arrangement of the mask. The target analytes may be non-invasively detected by differentiating the analyte response signal from the background signal due, at least in part, to the modulation of the analyte response signal.

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  • Balloon atherectomy catheters with imaging

    Filed US US14424277

    An atherectomy catheter includes an elongate flexible catheter body, a cutter near the distal end of the catheter body, a drive shaft connected to the cutter and extending within the catheter body, an imaging element near the distal end of the catheter body and an imaging shaft connected to the imaging element and extending within the catheter body. The cutter and the imaging element are mechanically isolated, and the drive shaft is configured to be axially translated relative to the imaging…

    An atherectomy catheter includes an elongate flexible catheter body, a cutter near the distal end of the catheter body, a drive shaft connected to the cutter and extending within the catheter body, an imaging element near the distal end of the catheter body and an imaging shaft connected to the imaging element and extending within the catheter body. The cutter and the imaging element are mechanically isolated, and the drive shaft is configured to be axially translated relative to the imaging shaft and the catheter body.

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  • Modulation of a response signal to distinguish between analyte and background signals

    Filed US PCT/US2014/061748

    A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the…

    A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background signal.

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  • Non-invasive analyte detection system with modulation source

    Filed US PCT/US2014/061784

    A system for modulating a response signal includes functionalized particles configured to interact with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response…

    A system for modulating a response signal includes functionalized particles configured to interact with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the interaction of the target analytes with the functionalized particles. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.

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  • Occlusion sheath for imaging catheter

    Filed US PCT/US2014/045132

    An occlusion sheath having an expandable member is described herein. The occlusion sheath is configured to occlude or limit blood flow to a vessel while providing a central lumen to allow a catheter, such as an imaging catheter and/or an atherectomy catheter, to travel therethrough.

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  • Occlusion-crossing devices

    Filed US US14433786

    A catheter device for crossing occlusions includes an elongate catheter shaft, a rotatable tip configured to rotate relative to the elongate catheter shaft, a drive shaft, and an OCT imaging sensor. The rotatable tip includes a housing coupled with the elongate catheter shaft and cutting wedges extendable from the housing. The drive shaft has a central lumen extending therethrough and extends within the elongate catheter shaft. The drive shaft is coupled with the wedges and is configured to…

    A catheter device for crossing occlusions includes an elongate catheter shaft, a rotatable tip configured to rotate relative to the elongate catheter shaft, a drive shaft, and an OCT imaging sensor. The rotatable tip includes a housing coupled with the elongate catheter shaft and cutting wedges extendable from the housing. The drive shaft has a central lumen extending therethrough and extends within the elongate catheter shaft. The drive shaft is coupled with the wedges and is configured to rotate the rotatable tip. The OCT sensor includes an optical fiber coupled with the rotatable tip and configured to rotate therewith. The elongate catheter shaft is configured to move axially over the drive shaft to extend and retract the wedges from the housing while maintaining a fixed position of the imaging sensor relative to the cutting wedges.

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  • Atherectomy catheters and occlusion crossing devices

    US11284916B2

    An atherectomy catheter includes an elongate flexible catheter body, a cutter near the distal end of the catheter body, a drive shaft connected to the cutter and extending within the catheter body, an imaging element near the distal end of the catheter body.

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  • Devices, systems, and methods for providing features to improve activity sport sessions

    US US20160136482A1

    Several methods, devices and systems that provide features for improved activity sport sessions are described. In one embodiment, a multifunctional device includes an inertial measurement unit to sense movements of an activity device (e.g., a board, a surfboard, a windsurfing board, etc.) during an activity sport session and to sense at least one input for indicating a target location during the activity sport session. The device also includes at least one processing unit coupled to the…

    Several methods, devices and systems that provide features for improved activity sport sessions are described. In one embodiment, a multifunctional device includes an inertial measurement unit to sense movements of an activity device (e.g., a board, a surfboard, a windsurfing board, etc.) during an activity sport session and to sense at least one input for indicating a target location during the activity sport session. The device also includes at least one processing unit coupled to the inertial measurement unit. The at least one processing unit is configured to designate a target location in response to the inertial measurement unit sensing an input for indicating the target location, to record the target location, to determine a current location of the activity device, and to compare the current location and the target location. In one example, the at least one processing unit is further configured to generate a directional output if the target location and current location are different.

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  • Method and system for prevention of surgical fires

    US US20130098365A1

    System and method for prevention of surgical fires inside a patient's airway. The system includes a specially adapted endotracheal tube which carries sublines (in addition to the main line carrying anesthetic gases) for carrying an air sample back from the distal end of the tube to a remote oxygen sensor. Upon the sensor sensing an undesirably or dangerously high level of oxygen within the patient's airway, the system operates alarms to alert the surgical personnel, and also operates a…

    System and method for prevention of surgical fires inside a patient's airway. The system includes a specially adapted endotracheal tube which carries sublines (in addition to the main line carrying anesthetic gases) for carrying an air sample back from the distal end of the tube to a remote oxygen sensor. Upon the sensor sensing an undesirably or dangerously high level of oxygen within the patient's airway, the system operates alarms to alert the surgical personnel, and also operates a controllable valve to admit an inert gas into other sublines associated with the endotracheal tube and which deliver the inert fire suppressing gas to the distal end of the tube, proximal to the cuff, inside the patient's airway.

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  • Positioning a wearable device for data collection

    US US20160007925A1

    Several methods, devices and systems that provide features for improved activity sport sessions are described. In one embodiment, a multifunctional device includes an inertial measurement unit to sense movements of an activity device (e.g., a board, a surfboard, a windsurfing board, etc.) during an activity sport session and to sense at least one input for indicating a target location during the activity sport session. The device also includes at least one processing unit coupled to the…

    Several methods, devices and systems that provide features for improved activity sport sessions are described. In one embodiment, a multifunctional device includes an inertial measurement unit to sense movements of an activity device (e.g., a board, a surfboard, a windsurfing board, etc.) during an activity sport session and to sense at least one input for indicating a target location during the activity sport session. The device also includes at least one processing unit coupled to the inertial measurement unit. The at least one processing unit is configured to designate a target location in response to the inertial measurement unit sensing an input for indicating the target location, to record the target location, to determine a current location of the activity device, and to compare the current location and the target location. In one example, the at least one processing unit is further configured to generate a directional output if the target location and current location are different.

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  • Test model for wearable devices

    US9451911B1

    A test model for simulating one or more physiological parameters is provided. In one example, the test model includes a model layer having a test surface, a shaft rotatably disposed within the model layer and at least first and second contrast segments circumferentially disposed on the shaft. The model layer models at least one optical property of human skin, such as transmissivity of at least a particular wavelength of light transmitted into the model layer. The first and second contrast…

    A test model for simulating one or more physiological parameters is provided. In one example, the test model includes a model layer having a test surface, a shaft rotatably disposed within the model layer and at least first and second contrast segments circumferentially disposed on the shaft. The model layer models at least one optical property of human skin, such as transmissivity of at least a particular wavelength of light transmitted into the model layer. The first and second contrast segments have contrasting optical properties with regard to at least the particular wavelength of light, such as reflectance. Rotation of the shaft causes different contrast segments to face the test surface of the model layer at different times.

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