About
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I’m happy to share that I’m starting a new position as Molecular Lab Technician at TruDiagnostic! I’m so excited to start my career with this company…
I’m happy to share that I’m starting a new position as Molecular Lab Technician at TruDiagnostic! I’m so excited to start my career with this company…
Liked by Hannah Went
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In less than 11 months, I reversed my biological age by 10 years. I achieved this despite having a copy of APOE4, two copies of MTHFR, and an LP(a)…
In less than 11 months, I reversed my biological age by 10 years. I achieved this despite having a copy of APOE4, two copies of MTHFR, and an LP(a)…
Liked by Hannah Went
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Throughout her career, Kamala Harris has a proven track record of championing LGBTQ+ rights. She is qualified, experienced, fierce as hell, and we’re…
Throughout her career, Kamala Harris has a proven track record of championing LGBTQ+ rights. She is qualified, experienced, fierce as hell, and we’re…
Liked by Hannah Went
Experience & Education
Publications
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Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions
Aging-US
Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), epigenetic age, and immune cell subsets. In a Phase I pilot study, 19 participants received DQ for 6 months, with DNAm measured at baseline, 3 months, and 6 months. Significant increases in epigenetic…
Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), epigenetic age, and immune cell subsets. In a Phase I pilot study, 19 participants received DQ for 6 months, with DNAm measured at baseline, 3 months, and 6 months. Significant increases in epigenetic age acceleration were observed in first-generation epigenetic clocks and mitotic clocks at 3 and 6 months, along with a notable decrease in telomere length. However, no significant differences were observed in second and third-generation clocks. Building upon these findings, a subsequent investigation evaluated the combination of DQ with Fisetin (DQF), a well-known antioxidant and antiaging senolytic molecule. After one year, 19 participants (including 10 from the initial study) received DQF for 6 months, with DNAm assessed at baseline and 6 months. Remarkably, the addition of Fisetin to the treatment resulted in non-significant increases in epigenetic age acceleration, suggesting a potential mitigating effect of Fisetin on the impact of DQ on epigenetic aging. Furthermore, our analyses unveiled notable differences in immune cell proportions between the DQ and DQF treatment groups, providing a biological basis for the divergent patterns observed in the evolution of epigenetic clocks. These findings warrant further research to validate and comprehensively understand the implications of these combined interventions.
Other authorsSee publication -
Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications
Journal of Neurosurgery
Michael M. Safaee MD, Varun B. Dwaraka PhD, Justin M. Lee BA, Marissa Fury BS, Tavis L. Mendez PhD, Ryan Smith BS, Jue Lin PhD, Dana L. Smith MS, John F. Burke MD, Justin K. Scheer MD, Hannah Went BS, Christopher P. Ames MD. (In review) Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications. medRxiv
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Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination
Frontiers
Pang APS, Higgins-Chen AT, Comite F, Raica I, Arboleda C, Went H, Mendez T, Schotsaert M, Dwaraka V, Smith R, Levine ME, Ndhlovu LC and Corley MJ (2022) Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination. Front. Genet. 13:819749. doi: 10.3389/fgene.2022.819749
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Effects of homogenizing methods on accuracy and precision of equine strongylid egg counts.
Veterinary Parasitology
Went, H.A. “Effects of homogenizing methods on accuracy and precision of equine strongylid egg counts.” Veterinary Parasitology, vol. 261, 15 Sept. 2018. pp. 91-95.
More activity by Hannah
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⏰ Epigenetic clocks make a splash on the season finale of Keeping up with the Kardashians! 🤯 Exciting to witness The Kardashians using…
⏰ Epigenetic clocks make a splash on the season finale of Keeping up with the Kardashians! 🤯 Exciting to witness The Kardashians using…
Liked by Hannah Went
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The NYC longevity medicine ecosystem is growing fast!
The NYC longevity medicine ecosystem is growing fast!
Liked by Hannah Went
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I'm so excited to be attending ARDD in person this year in Copenhagen! Shoot me a message if you'll be there so we can chat and catch up.
I'm so excited to be attending ARDD in person this year in Copenhagen! Shoot me a message if you'll be there so we can chat and catch up.
Shared by Hannah Went
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As I begin a 3-week adventure exploring the US with my family, I wish to express my gratitude to all my podcast guests and listeners by sharing short…
As I begin a 3-week adventure exploring the US with my family, I wish to express my gratitude to all my podcast guests and listeners by sharing short…
Liked by Hannah Went
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It's tough to argue for a better overall marker of health than the pace of one's biological aging. Very excited to see this becoming more mainstream…
It's tough to argue for a better overall marker of health than the pace of one's biological aging. Very excited to see this becoming more mainstream…
Liked by Hannah Went
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Fresh off a fascinating Webinar hosted by Illumina where Ryan Smith from TruDiagnostic zipped through the myriad discoveries, processes…
Fresh off a fascinating Webinar hosted by Illumina where Ryan Smith from TruDiagnostic zipped through the myriad discoveries, processes…
Liked by Hannah Went
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