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Articles by Susan
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July is Disability Pride Month. This article includes a helpful chart on language dos and dont's + info on being an ally. ❤️
July is Disability Pride Month. This article includes a helpful chart on language dos and dont's + info on being an ally. ❤️
Liked by Susan Huang
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Excited to be speaking at MGMA in October this year! Hope to see you there!
Excited to be speaking at MGMA in October this year! Hope to see you there!
Liked by Susan Huang
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Proud to serve at Sharp HealthCare and deliver on The Sharp Experience - best place to work, best place to practice medicine, and best place to…
Proud to serve at Sharp HealthCare and deliver on The Sharp Experience - best place to work, best place to practice medicine, and best place to…
Liked by Susan Huang
Experience & Education
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Providence
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Publications
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Machine learning for clinical operations improvement via case triaging
Skin Health and Disease
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Analysis of patient preferences on patient-provider interactions through the OpenNotes online portal in dermatology
International Journal of Women’s Dermatology
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Covid19: A catalyst for innovative hybrid teledermatology workflows to increase access and improve patient care at a large group practice
Journal of the American Academy of Dermatology
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Changes in sex and racial diversity in academic dermatology faculty over 20 years
Journal of the American Academy of Dermatology
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Rapidly progressive nonuremic calciphylaxis in the setting of warfarin
American Journal of Medicine
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Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin.
Journal of Investigative Dermatology
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Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
Nature
The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic product 8-oxoguanine (oxoG). Replicative DNA polymerases misread oxoG residues and insert adenine instead of cytosine opposite the oxidized base. Both bases in the resulting A*oxoG mispair are mutagenic lesions, and both must undergo base-specific replacement to restore the original C*G pair. Doing so represents a formidable challenge to the DNA repair machinery, because adenine makes up roughly 25% of the…
The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic product 8-oxoguanine (oxoG). Replicative DNA polymerases misread oxoG residues and insert adenine instead of cytosine opposite the oxidized base. Both bases in the resulting A*oxoG mispair are mutagenic lesions, and both must undergo base-specific replacement to restore the original C*G pair. Doing so represents a formidable challenge to the DNA repair machinery, because adenine makes up roughly 25% of the bases in most genomes. The evolutionarily conserved enzyme adenine DNA glycosylase (called MutY in bacteria and hMYH in humans) initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. A central issue concerning MutY function is the mechanism by which A*oxoG mispairs are targeted among the vast excess of A*T pairs. Here we report the use of disulphide crosslinking to obtain high-resolution crystal structures of MutY-DNA lesion-recognition complexes. These structures reveal the basis for recognizing both lesions in the A*oxoG pair and for catalysing removal of the adenine base.
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More activity by Susan
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One of the innovations in healthcare that I’m most excited about right now is the shift to online/virtual therapy. In a world where access to…
One of the innovations in healthcare that I’m most excited about right now is the shift to online/virtual therapy. In a world where access to…
Liked by Susan Huang
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Survey data from four European countries indicate that patients place greater importance on patient-reported outcome measures than on…
Survey data from four European countries indicate that patients place greater importance on patient-reported outcome measures than on…
Liked by Susan Huang
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MY REFLECTIONS FROM PARENTAL LEAVE, MORE INVIGORATED THAN EVER TO GET BACK SERVING VETS My wife and I were blessed to welcome Mazen Elnahal, our…
MY REFLECTIONS FROM PARENTAL LEAVE, MORE INVIGORATED THAN EVER TO GET BACK SERVING VETS My wife and I were blessed to welcome Mazen Elnahal, our…
Liked by Susan Huang
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